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The advantages of FISH for detecting NTRK gene fusions are summarised in the following table.

Table 26: Advantages of FISH for Testing for NTRK Gene Fusions


  • Relatively quick
  • Does not require much tumour tissue or high tumour content for a single test [1]
  • Usually high specificity and sensitivity for DNA level rearrangements within a single given gene [2]
  • Can be performed on many types of biopsy specimens including [1] formalin-fixed paraffin-embedded tissue sections [3, 4]


  1. Savic S, Bubendorf L. Common Fluorescence In Situ Hybridization Applications in Cytology. Arch Pathol Lab Med 2016; 140: 1323-1330.
  2. Cui C, Shu W, Li P. Fluorescence In situ Hybridization: Cell-Based Genetic Diagnostic and Research Applications. Front Cell Dev Biol 2016; 4: 89.
  3. Choi Y, Won YJ, Lee S et al. Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer. Transl Oncol 2018; 11: 764-770.
  4. Ou SH. Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond. Drug Des Devel Ther 2011; 5: 471-485.

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