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Poster display

309 - Up-regulation of miR-1266-5p suppressed hTERT expression and telomerase activity in cancer cell lines

Date

05 Mar 2018

Session

Poster display

Presenters

S Saied Hosseini-Asl

Citation

Annals of Oncology (2018) 29 (suppl_3): iii10-iii34. 10.1093/annonc/mdy047

Authors

S.S. Hosseini-Asl1, S. Sorayyayi2, S. Vahidi2

Author affiliations

  • 1 Genetics, Ardabil University of Medical Sciences, 0100 - Ardabil/IR
  • 2 Biochemistry, Ardabil University of Medical Sciences, 000 - Rasht/IR
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Resources

Abstract 309

Telomerase is in charge of telomere extending and is triggered in around 90% of cancers. hTERT is the controlling subunit of telomerase and plays a critical role in the activation of telomerase. The mechanism through which hTERT regulate the invasion and metastasis of cancer is unclear. miRNAs can regulate the expression of hTERT. It was previously reported that miR-1266 can target hTERT in gastric cancer. In this study, we have made the first report of miR-1266-5p role on the hTERT expression, telomerase activity, and biological functions, including cell proliferation and cell cycle in AGS, MCF7, A375, and HepG2 cell lines.

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