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Poster display

200 - Introduction of a novel cancer cell targeted fusion protein: DT386-BR2

Date

05 Mar 2018

Session

Poster display

Presenters

Ali Jahanian-Najafabadi

Citation

Annals of Oncology (2018) 29 (suppl_3): iii10-iii34. 10.1093/annonc/mdy047

Authors

A. Jahanian-Najafabadi1, F. Shafiee1, M. Rabbani2

Author affiliations

  • 1 Department Of Pharmaceutical Biotechnology, Isfahan University of Medical Sciences, 8174673461 - Isfahan/IR
  • 2 Department Of Pharmacology And Toxicology, Isfahan University of Medical Sciences, 8174673461 - Isfahan/IR
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Resources

Abstract 200

Due to the adverse side effects of current cancer chemotherapeutics development of targeted anti-cancer medications is under intensive focus. In the present study a fusion protein consisting of the catalytic and translocation domains of diphtheria toxin fused to BR2, a cancer specific cell penetrating peptide, was produced as a new targeted anti-cancer agent and its cytotoxic effects on various cell lines including MCF-7 and HeLa (as cancerous), and HEK293 and HUVEC (as normal) cell lines was evaluated.

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