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Novel epigenetic targets

16 - HDAC inhibitors and check point inhibitors


05 Mar 2018


Novel epigenetic targets


René Bartz


Annals of Oncology (2018) 29 (suppl_3): iii1-iii6. 10.1093/annonc/mdy046


R. Bartz

Author affiliations

  • -, 4SC AG, 82152 - Planegg/DE


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Abstract 16

Despite successes in the treatment of melanoma patients with checkpoint inhibitors (CI), most patients do not respond to CI alone and a high unmet medical need remains for these patients. One promising approach is to enhance the immunogenicity and alter the tumor microenvironment from a more immune-deserted to an immune-inflamed phenotype by means of combination therapy. Epigenetic modulation has been reported as one key determining factor in shaping the immune microenvironment and compounds altering these processes (e.g. histone deacetylases (HDAC) inhibitors) are particularly promising.

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