Urinary bladder cancer is the ninth most common malignancy in the Uzbekistan. 94% cases of urinary bladder cancer made up urothelial carcinoma (UC). There were limited options for patients who are refractory to systemic chemotherapy. Targeted agents as EGFR/HER2 has been proved in a wide range of cancers, but no studies have yet clarified the clinicopathological significance of them in UC. The aim of this study is determination of EGFR/HER2 overexpression which would widen therapeutic options for patients with advanced UC.