Lymph nodes (LNs) are an essential organ in an immune system, and lymphatic vessels connect them. Their primary function is to maintain the health of the body via filtering morbific material from the lymphatic fluid. In the case of cancer metastasis, cancer cells are disseminated from primary tumor via the bloodstream to the distant sites. Clinically, detection of metastasis within sentinel lymph node (SLNs) is significantly predictive of prognosis with implications for the patient's survival and adjuvant therapy. The limited studies available report that dissection of normal lymph nodes (LNs) is involved in the activation and rapid growth of latent tumors in distant metastasis.