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Proffered Paper Session 1

187 - A first-in-human first-in-class (FIC) trial of the monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with advanced solid tumours

Date

05 Mar 2018

Session

Proffered Paper Session 1

Presenters

Ruth Plummer

Citation

Annals of Oncology (2018) 29 (suppl_3): iii7-iii9. 10.1093/annonc/mdy048

Authors

R. Plummer1, S. Halford2, P. Jones2, S. Wedge3, S. Hirschberg2, G. Veal1, G. Payne4, M. Chenard-Poirier4, H. Keun5, U. Banerji6

Author affiliations

  • 1 Newcastle University, NE2 4HH - Newcastleupon Tyne/GB
  • 2 Cancer Research UK Angel Building, London/GB
  • 3 Newcastle University, Newcastle upon Tyne/GB
  • 4 Institute of Cancer Research ICR, London/GB
  • 5 Imperial College London - Hammersmith Hospital, London/GB
  • 6 Drug Development Unit  , The Institute of Cancer Research/Royal Marsden NHS Foundation Trust, SM2 5PT - Sutton/GB
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Resources

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Abstract 187

A key metabolic alteration in tumour cells is increased dependency on glycolysis, resulting in the production of lactate which is transported out of cells by MCTs. Inhibition of MCT-1 can constrain cancer cell growth in preclinical models. We report results on the phase I study of AZD3965, a FIC inhibitor of MCT-1.

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