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e-Posters

50P - Transcriptomic Analysis of Host Immune Response for Precision Drug Prediction for SARS-CoV-2 Infected Patients- An Evidence-Based Approach

Date

06 Oct 2021

Session

e-Posters

Presenters

Arwa Bohra

Citation

Annals of Oncology (2021) 32 (suppl_6): S1345-S1371. 10.1016/annonc/annonc740

Authors

A. Bohra

Author affiliations

  • All India Institute of Medical Sciences Bhopal, Bhopal/IN
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Abstract 50P

Background

SARS-CoV-2 Virus can trigger severe pneumonia and lead to acute respiratory distress syndrome. Data from clinical, in vitro, and in vivo suggest that virus-induced cytokine dysregulation is a contributory factor to the pathogenesis. Drugs targeting the same are being tried.

Methods

To obtain a better understanding of the molecular events, we studied the transcriptome of infected macrophages and obtained a list of incriminated pathways using Gene Set Enrichment Analysis. Co-expression gene analysis was further used to predict drug targets.

Results

Immune system, hemostasis, RNA metabolism, cellular response to external stimuli, vesicle- mediated transport, cell cycle mechanisms, DNA replication, and repair are upregulated. Interferon alpha, beta, and gamma are upregulated. IL-1,6,10, 13, TNF NF-KB are upregulated. Signaling by non-receptor tyrosine kinase, NOTCH, Sonic Hedgehog, lLeptin, MAP kinase-6, 4, and estrogen-mediated signaling are increased. Olfactory sensation, transmission across chemical synapses, and sperm motility appear to be downregulated. Disease host signature has resemblance with cystic fibrosis, thrombophilia, leishmania, influenza, CMV, HIV and SARS infection, and diseases of programmed cell death like neurodegenerative diseases. We have predicted 24 precise drugs which can be explored in clinical trials of SARS-CoV 2 treatment.

Conclusions

Our study provides important mechanistic insights into the understanding of SARS-CoV-2 viral pathogenesis and the multi-faceted host immune responses.

Legal entity responsible for the study

AIIMS Bhopal.

Funding

Has not received any funding.

Disclosure

The author has declared no conflicts of interest.

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