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e-Poster Display Session

2P - Role of neutrophil-to-lymphocyte ratio (NLR) in the outcome of NSCLC EGFR mutated

Date

24 Mar 2021

Session

e-Poster Display Session

Presenters

Simona Tolu

Citation

Journal of Thoracic Oncology (2021) 16 (suppl_4): S699-S703.

Authors

S. Tolu1, G. Saba2, V. Impera3, D. Spanu2, N. Liscia3, G. Pinna2, A. Pireddu3, L. Demurtas2, E. Lai2, F. Manca2, C. Madeddu2, E. Massa4, G. Astara2, M. Scartozzi2

Author affiliations

  • 1 Medical Oncology, University of Cagliari - Sapienza Università di Roma, Monserrato (CA)/IT
  • 2 University of Cagliari, 9042 - Monserrato (CA)/IT
  • 3 University of Cagliari - Sapienza Università di Roma, 9042 - Monserrato (CA)/IT
  • 4 Monserrato/IT
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Abstract 2P

Background

Systemic inflammation promotes angiogenesis and cell proliferation, which play key roles during carcinogenesis. Several studies have shown a strong link between inflammation index and prognosis in non-small cell lung cancer (NSCLC). The aim of our study is to investigate the role of NLR at diagnosis in the outcome of NSCLC EGFR mutated.

Methods

Our retrospective analysis included 103 eligible patients (pts), including 40 pts with EGFR wild type (wt) NSCLC and 63 pts with EGFR mutated NSCLC. Inclusion criteria were over 18 years of age, diagnosis of NSCLC, availability of a pre-treatment complete blood count. Exclusion criteria were active infections, autoimmune diseases, use of corticosteroids. The NLR was derived from the absolute neutrophil and the absolute lymphocyte counts. The cutoff value was determined through the use of ROC curves and through the distinction, based on overall survival (OS) at 12 months, between pts with good and bad prognosis. For each subgroup of mts, median OS was assessed. Statistical processing was performed with the aim of correlating the haematological data collected with the clinical outcome.

Results

In pts EGFR wt the NLR cut-off obtained was 3.18., in pts EGFR mutaded the cut-off was 3,5. Pts who have a value less than or equal to cut-off have a better prognosis, compared to pts who have a NLR higher than have a worse prognosis. As a pts EGFR wt the median best OS was 41.33 months, while the worst OS was a median of 10.33 months, with a difference of 31 months (p = 0.0003). In case of pts EGFR mutaded the best median OS was 21 and the worst 8,3 months, with a difference of 13 months (p = 0,013). There were no significant differences in age, ECOG PS, histology, size, therapies or treatment line.

Conclusions

The NLR remains a prognostic factor in both diseases, with or without EGFR mutation, but appear to have less impact on the outcome of EGFR mutated patients. In NSCLC EGFR mutated maybe inflammatory index could have implications on therapeutic choice, especially subsequent lines and his role deserves further study.

Legal entity responsible for the study

Mario Scartozzi.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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