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e-Poster Display Session

11P - LINC00926 is a B cell-specific long noncoding RNA in lung adenocarcinoma and is associated with the prognosis of patients with this disease

Date

24 Mar 2021

Session

e-Poster Display Session

Presenters

Jiawei Li

Citation

Journal of Thoracic Oncology (2021) 16 (suppl_4): S699-S703.

Authors

J. Li1, H. Guo2, Y. Ma3, H. Chen4, M. Qiu4

Author affiliations

  • 1 Peking University People's Hospital, Beijing/CN
  • 2 Beijing Chest Hospital, 101149 - Beijing/CN
  • 3 Thoracic Surgery, Peking University People's Hospital, 100044 - Beijing/CN
  • 4 Peking University People's Hospital, 100044 - Beijing/CN
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Abstract 11P

Background

A previous report has shown that LINC00926 might be involved in the suppression of breast cancer metastasis. However, studies regarding the function of LINC00926 in lung adenocarcinoma are rare.

Methods

10X single cell RNA sequencing (scRNA-seq) data of 8 healthy lung tissues and 5 lung adenocarcinoma tissues were obtained from our previous study. The sequence of LINC00926 was obtained from Noncode (http://www.noncode.org/) and the cellular location of the lncRNAs was predicted by lncLocator (http://www.csbio.sjtu.edu.cn/bioinf/lncLocator/). The target miRNA of the lncRNAs were predicted by Starbase (http://starbase.sysu.edu.cn/). The target genes of miRNA were predicted by miRDB (http://mirdb.org/). Functional annotation of the target genes was made by DAVID (https://david.ncifcrf.gov/). The overall survival of patients in TCGA-LUAD with different expression level of LINC00926 was compared by GEPIA (http://gepia.cancer-pku.cn/).

Results

LINC00926 was specifically expressed in B cells in lung adenocarcinoma. However, LINC00926 was not expressed in B cells in normal lungs. LINC00926 was mainly located in the cytoplasm, suggesting that LINC00926 might function through RNA-sponge. LINC00926 could bind the microRNA hsa-miR-3194-5p. The target genes of hsa-miR-3194-5p were enriched in Gene Ontology (GO) terms such as cell junction, protein kinase binding and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways such as Ras signaling pathway. High expression of LINC00926 was associated with better overall survival of patients with lung adenocarcinoma.

Conclusions

LINC00926 might be a B-cell specific marker and might play a protective role in patients with lung adenocarcinoma. Further research is needed to explore how LINC00926 functions in patients with lung adenocarcinoma.

Legal entity responsible for the study

Mantang Qiu.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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