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Diagnostic value of concomitant use of radial probe endobronchial ultrasound with guide sheath and transbronchial biopsy in lung cancer


05 Apr 2019


Sang Chul Lee


Annals of Oncology (2019) 30 (suppl_2): ii74-ii76. 10.1093/annonc/mdz065


S.C. Lee1, S. Kwak2, M.S. Park2, Y.S. Kim2, J. Chang2, S.H. Lee2, C.H. Han1, S.M. Lee1, C.J. Kim1

Author affiliations

  • 1 Division Of Pulmonology, Department Of Internal Medicine, National Health Insurance Service Ilsan Hospital, 10444 - Goyang/KR
  • 2 Yonsei University College of Medicine Department of Internal Medicine, Seoul/KR



Although using radial endobronchial ultrasound with guide sheath (r-EBUS-GS) has shown its diagnostic power in peripheral pulmonary lesion, its actual utility is still low due to variable diagnostic performance. To overcome its limitation, we evaluated the feasibility and efficacy of r-EBUS-GS when combined with transbronchial biopsy (TBB).


We retrospectively reviewed the medical records of 74 patients with NSCLC who underwent r-EBUS-GS plus TBB or TBB alone as diagnostic methods between 2017 Aug. and 2018 Nov. at the Severance hospital. Subjects were grouped by diagnostic modalities used (r-EBUS-GS plus TBB vs. TBB alone). Each group was matched by age, sex, biopsy location. Chi-square analysis and paired-t test were used to compare the characteristics, and to find the factors which affect to the diagnostic yield.


In each group, the number of male subjects was 21 and their mean age was 67.5 and 67.3, respectively. Lesion size was statistically smaller in r-EBUS-GS group. Although r-EBUS-GS alone (15/37, 40.5%) showed poor diagnostic yield, combination of r-EBUS-GS and TBB (27/37, 72.9%) showed higher than TBB alone group (23/37, 62.1%). Lung lesion with bronchus sign was associated with a higher diagnostic yield. (OR = 3.23 (1.17-8.90); p = 0.021).


Combination of r-EBUS-GS and TBB has higher diagnostic power than using r-EBUS-GS or TBB alone.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.


Has not received any funding.


All authors have declared no conflicts of interest.

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