ESMO Virtual Advanced Course on NTRK Gene Fusion: A New Target in Precision Treatment of Cancer 2021

Slides and Webcasts from all ESMO Advanced Courses are reserved to ESMO Members and registered participants, according to the presenters' agreement to release them. ESMO thanks the authors for their generosity.

The copyright protected educational resources from this event are for personal usage only and not to be shared with any third parties.

Learning Objectives

• Acquire knowledge of the TRK family members and their roles in ontogenesis
• Understand the mechanisms of gene fusion and the different fusion partners involved
• Learn how TRK receptors are structured and how their activation impacts signal transduction
• Review the epidemiology of NTRK gene fusion in human tumours
• Understand the methodology to identify NTRK gene fusion and the challenges of testing
• Update knowledge on the present outcome obtained with NTRK inhibitors, their toxicities and clinical management