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Proffered Papers 2: Individual targets

16O - Phase I study of CC-90010, a reversible, oral BET inhibitor in patients (Pts) with advanced solid tumors (STs) and relapsed/refractory non-Hodgkin lymphoma (R/R NHL)


03 Mar 2020


Proffered Papers 2: Individual targets


Victor Moreno


Annals of Oncology (2020) 31 (suppl_1): S8-S10. 10.1016/annonc/annonc82


V. Moreno1, I. Braña2, J.M. Sepulveda Sanchez3, M. Vieito Villar2, T. Hernández Guerrero1, B. Doger4, O. Saavedra5, A. Pinto6, C. Carlo Stella7, A. Italiano8, J. Michot9, G. Musuraca10, R. Sarmiento11, J. De Alvaro11, M. Zuraek12, T. Sánchez-Pérez11, I. Aronchik12, E. Filvaroff12, B. Hanna12, Z. Nikolova11

Author affiliations

  • 1 START Madrid-FJD, Hospital Universitario Fundación Jimenez Diaz, 28040 - Madrid/ES
  • 2 Hospital Universitari Vall d’Hebron, 08035 - Barcelona/ES
  • 3 Hospital Universitario 12 de Octubre, 28041 - Madrid/ES
  • 4 START Madrid-FJD, Hospital Universitario Fundación Jimenez Diaz, Madrid/ES
  • 5 Hospital Universitari Vall d’Hebron, Barcelona/ES
  • 6 Istituto Nazionale Tumori IRCSS Fondazione Pascale, Naples/IT
  • 7 Humanitas Cancer Center, Humanitas Clinical and Research Center, Milan/IT
  • 8 Institut Bergonie Centre Regional de Lutte Contre Le Cancer de Bordeaux Et Sud Ouest, 33076 - Bordeaux/FR
  • 9 Department Of Hematology, Institut Gustave Roussy, 94800 - Villejuif/FR
  • 10 Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori (IRST), Meldola/IT
  • 11 Celgene, A Bristol-Myers Squibb Company, Summit/US
  • 12 Bristol-Myers Squibb, Summit/US


Abstract 16O

Bromodomain and extra-terminal (BET) proteins are epigenetic readers that regulate expression of genes involved in oncogenesis. CC-90010 is a potent BET inhibitor that showed preliminary antitumor activity in pts with advanced malignancies.

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