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Poster Display & Cocktail

23P - Novel ERα degrader, 3,20(R)-dihydroxy-19-norpregnatriene, inhibits MCF-7 cell growth through p21/CDK2/CDK4 pathway

Date

02 Mar 2020

Session

Poster Display & Cocktail

Presenters

Alexander Scherbakov

Citation

Annals of Oncology (2020) 31 (suppl_1): S10-S13. 10.1016/annonc/annonc85

Authors

A.M. Scherbakov1, I.S. Levina2, Y. Kuznetsov2, M. Tserfas2, I. Zavarzin2

Author affiliations

  • 1 Oncoproteomics Laboratory, N.N. Blokhin National Medical Research Center of Oncology, 115522 - Moscow/RU
  • 2 N.D. Zelinsky Institute of Organic Chemistry, 119991 - Moscow/RU
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Resources

Abstract 23P

Breast cancer is the most common cancer in women. There is an urgent need for new drugs with novel modes of effect on tumors. It is very important to develop compounds with high activity against tumor cells and low toxicity on normal epithelium. The development of new anti-tumor drugs based on steroidal compounds is a promising approach for obtaining agents that combine antiestrogenic, cytostatic and proapoptotic effects. The aim of the work is to study the mechanism of anticancer action of new steroidal compound, 3,20 (R)-dihydroxy-19-norpregnatriene (Kuz7).

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