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Proffered Papers 1: Immunotherapy

1O - Inducible T cell co-stimulatory (ICOS) receptor agonist, GSK3359609 (GSK609) alone and combination with pembrolizumab: Preliminary results from INDUCE-1 expansion cohorts in head and neck squamous cell carcinoma (HNSCC)

Date

02 Mar 2020

Session

Proffered Papers 1: Immunotherapy

Presenters

Christophe Le Tourneau

Citation

Annals of Oncology (2020) 31 (suppl_1): S1-S7. 10.1016/annonc/annonc86

Authors

C. Le Tourneau1, D. Rischin2, S. Groenland3, A. Lim4, J. Martin-Liberal5, V. Moreno6, J.M. Trigo7, M. Mathew8, D. Cho9, A. Hansen10, D. Vincente Baz11, M. Maio12, A. Italiano13, J. Bauman14, M. Chisamore15, H. Zhou16, C. Ellis16, M. Ballas16, A. Hoos16, E. Angevin17

Author affiliations

  • 1 Institut Curie, 75248 - Paris/FR
  • 2 Peter MacCallum Cancer Centre and the University of Melbourne, Melbourne/AU
  • 3 Antoni Van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam/NL
  • 4 Linear Clinical Research and Sir Charles Gairdner Hospital, Nedlands/AU
  • 5 Vall d’Hebron Institute of Oncology (VHIO)-Cellex Cente, Barcelona/ES
  • 6 START Madrid-FJD, University Hospital "Fundacion Jimenez Diaz", Madrid/ES
  • 7 Hospital Universitario Virgen de la Victoria, Málaga/ES
  • 8 Columbia University Medical Center, New York/US
  • 9 New York University Langone Medical Center, New York/US
  • 10 Princess Margaret Cancer Center, Toronto/CA
  • 11 Hospital Universitario Virgen Macarena, Sevilla/ES
  • 12 University Hospital of Siena, Siena/IT
  • 13 Institut Bergonié, Bordeaux/FR
  • 14 Fox Chase Cancer Center, Philadelphia/US
  • 15 Merck & Co., Inc, North Wales/US
  • 16 GSK, Collegeville/US
  • 17 Gustave Roussy Institut de Cancérologie, Villejuif/FR
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Resources

Abstract 1O

INDUCE-1 is a first-in-human study investigating GSK609 alone (mono) and in combination (combo) with other regimens including pembrolizumab (pembro). The study consists of dose escalation (DE) and expansion phases. Findings from DE and PK/PD mono cohorts demonstrated that a range of GSK609 doses (≥0.1-1 mg/kg) have biological and clinical activity supporting the mechanism of action of a non-T cell depleting IgG4 ICOS agonist antibody as a clinical target.

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