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Poster Display & Cocktail

10P - In vitro and in vivo cytolethal and antitumor effects of a novel fusion protein targeting IL-24 toward breast cancer cells


02 Mar 2020


Poster Display & Cocktail


Translational Research;  Breast Cancer


Ali Jahanian-Najafabadi


Annals of Oncology (2020) 31 (suppl_1): S1-S7. 10.1016/annonc/annonc86


A. Jahanian-Najafabadi, R. Ghavimi, V. Akbari

Author affiliations

  • Department Of Pharmaceutical Biotechnology, Isfahan University of Medical Sciences and Health Services, 8174673461 - Isfahan/IR


Abstract 10P

Interleukin-24 (IL-24) is known to selectively induce apoptosis in cancer cells through endoplasmic reticulum (ER) stress when it is expressed inside the cells. However, IL-24 alone is unable to enter the cells and consequently unable to inhibit cell proliferation. In the present study, we developed a novel chimeric protein, P28-IL-24, containing IL-24 which is linked to P-28, a defined cancer specific cell penetrating peptide and a P53 stabilizer, to target IL-24 into breast cancer cells. Afterwards, specific and non-specific cytolethal effect of this fusion protein were evaluated in vitro and in vivo.

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