Abstract 32P
Hypoxia is an extremely important condition for tumor metabolism. The cellular response to hypoxia is mainly mediated by the hypoxia-inducible factor (HIF) family of transcription factors, which regulate the expression of multiple genes engaged in different processes that lead to adaptation, progression and drug resistance of cancers. CA9 (CA IX) is a gene controlled by HIF-1α and is one of two tumor-associated carbonic anhydrase isoenzymes known. We aimed to obtain water-soluble derivatives of quinoxaline 1,4-dioxides targeting HIF-1α/CA9 path in breast cancer cells.