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Poster Display & Cocktail

32P - Evaluation of novel hypoxia-selective antitumor agents blocking HIF-1α/CA9 axis in breast cancer


02 Mar 2020


Poster Display & Cocktail


Galina Buravchenko


Annals of Oncology (2020) 31 (suppl_1): S13-S15. 10.1016/annonc/annonc83


G.I. Buravchenko1, A.M. Scherbakov2, D. Sorokin3, L. Fidalgo4, A.E. Shchekotikhin5

Author affiliations

  • 1 Biochemistry, FSBI Gause Institute of New Antibiotics, 119021 - Moscow/RU
  • 2 Laboratory Of Oncoproteomics, N.N. Blokhin National Medical Research Center of Oncology, 115522 - Moscow/RU
  • 3 Department Of Experimental Tumor Biology, N.N. Blokhin National Medical Research Center of Oncology, 115478 - Moscow/RU
  • 4 Departamento De Parasitología, Institute of Tropical Medicine Pedro Kouri, Habana/CU
  • 5 Laboratory Of Chemical Transformation Of New Antibiotics, Gause Institute of New Antibiotics, 119021 - Moscow/RU


Abstract 32P

Hypoxia is an extremely important condition for tumor metabolism. The cellular response to hypoxia is mainly mediated by the hypoxia-inducible factor (HIF) family of transcription factors, which regulate the expression of multiple genes engaged in different processes that lead to adaptation, progression and drug resistance of cancers. CA9 (CA IX) is a gene controlled by HIF-1α and is one of two tumor-associated carbonic anhydrase isoenzymes known. We aimed to obtain water-soluble derivatives of quinoxaline 1,4-dioxides targeting HIF-1α/CA9 path in breast cancer cells.

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