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Proffered Papers 2: Individual targets

18O - CC-90011 in patients (Pts) with advanced solid tumors (STs) and relapsed/refractory non-Hodgkin lymphoma (R/R NHL): Updated results of a phase I study


03 Mar 2020


Proffered Papers 2: Individual targets


Antoine Hollebecque


Annals of Oncology (2020) 31 (suppl_1): S8-S10. 10.1016/annonc/annonc82


A. Hollebecque1, J.S. de Bono2, S. Salvagni3, R. Plummer4, P. Niccoli5, J. Capdevila6, G. Curigliano7, V. Moreno8, F. De Braud9, M. López-Brea10, P. Martin-Romano11, E. Baudin1, M. Arias12, J. De Alvaro12, J. Parra-Palau12, T. Sánchez-Pérez12, I. Aronchik13, E. Filvaroff13, M. Lamba13, Z. Nikolova12

Author affiliations

  • 1 Institut Gustave Roussy, 94805 - Villejuif/FR
  • 2 The Institute of Cancer Research and Royal Marsden, SW7 3RP - London/GB
  • 3 Policlinico S. Orsola Malpighi University Hospital, 40138 - Bologna/IT
  • 4 Translational and Clinical Research Institute, Newcastle University, DN - Newcastle/GB
  • 5 Institut Paoli-Calmettes, Marseille/FR
  • 6 Vall d´Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona/ES
  • 7 Istituto Europeo di Oncologia, IRCCS, University of Milano, 20141 - Milan/IT
  • 8 START Madrid-FJD, Hospital Fundación Jiménez Díaz, 28040 - Madrid/ES
  • 9 Istituto Nazionale dei Tumori, Milan/IT
  • 10 H.U. Marqués de Valdecilla, Santander/ES
  • 11 Institut Gustave Roussy, Villejuif/FR
  • 12 Celgene, A Bristol-Myers Squibb Company, Summit/US
  • 13 Bristol-Myers Squibb, Summit/US


Abstract 18O

CC-90011 is an oral, potent, selective, and reversible inhibitor of lysine-specific demethylase 1A. Prior results from the CC-900011-ST-001 study showed that CC-90011 was well tolerated and had promising preliminary antitumor activity in pts with advanced unresectable STs and R/R NHL. Here we present updated results with longer follow-up and additional pts.

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