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Assessing the potential role of RICTOR expression as predictive factor of response to PI3K/mTOR pathway inhibitors in preclinical models of squamous cell lung cancer

Date

02 Mar 2020

Session

Poster Display & Cocktail

Presenters

Anastasios Gkountakos

Citation

Annals of Oncology (2020) 31 (suppl_1): S13-S15. 10.1016/annonc/annonc83

Authors

A. Gkountakos1, M. Simbolo1, C. Vicentini2, R.T. Lawlor2, L. Veghini1, S. Pilotto3, V. Ludovini4, R. Chiari4, S. Novello5, G. Tortora6, M. Milella3, A. Scarpa7, V. Corbo7, E. Bria6

Author affiliations

  • 1 Department Of Diagnostics And Public Health, Section Of Anatomical Pathology, University and Hospital Trust of Verona, 37134 - Verona/IT
  • 2 Arc-net Research Centre, University and Hospital Trust of Verona, Verona/IT
  • 3 Department Of Medicine, Section Of Medical Oncology, University of Verona, AOU Integrata, 37134 - Verona/IT
  • 4 Division Of Medical Oncology, S. Maria della Misericordia Hospital, University of Perugia, 06156 - Perugia/IT
  • 5 Thoracic Oncology Unit, San Luigi Hospital, University of Turin, 10043 - Orbassano/IT
  • 6 Medical Oncology, Università Cattolica Del Sacro Cuore, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS Rome, 00168 - Rome/IT
  • 7 Arc-net Research Centre And Department Of Diagnostics And Public Health, Section Of Anatomical Pathology, University and Hospital Trust of Verona, 37134 - Verona/IT
More

Resources

Amplification of RICTOR has been suggested to drive PI3K/mTOR pathway activation in squamous cell lung cancer (SQLC), representing a potential predictive biomarker of response to targeted therapy. Here, we sought to perform a thorough validation of RICTOR as predictive biomarker in SQLC preclinical models before advancing potential intervention strategies to the clinic.

Resources from the same session

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