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Proffered Papers 2: Individual targets

19O - A phase Ib trial of CFI-402257 in combination with weekly paclitaxel in patients with advanced HER2-negative (HER2-) breast cancer (aBC)


03 Mar 2020


Proffered Papers 2: Individual targets


Philippe Bedard


Annals of Oncology (2020) 31 (suppl_1): S8-S10. 10.1016/annonc/annonc82


P. Bedard1, M. Mates2, K.A. Gelmon3, J. Hilton4, D. Tu5, I. Li1, L. Rastgou6, N. Drummond-Ivars4, J. Edwards2, D. Warr1, C. Lohrisch7, X. song4, A. Srikanthan4, A. Robinson2, L. Hagerman5, L.K. Seymour8, M. Rushton8, D.W. Cescon1

Author affiliations

  • 1 Princess Margaret Cancer Center, M5G 2M9 - Toronto/CA
  • 2 Cancer Centre of Southeastern Ontario, K7L 5P9 - Kingston/CA
  • 3 Medical Oncology Department, BC Cancer, V5Z 4E6 - Vancouver/CA
  • 4 Medical Oncology Dept, The Ottawa Hospital Regional Cancer Centre, K1H 8L6 - Ottawa/CA
  • 5 Canadian Clinical Trials Group, Kingston/CA
  • 6 Medical Oncology Department, BC Cancer Agency - Vancouver, V5Z 4E6 - Vancouver/CA
  • 7 BC Cancer Agency - Vancouver, V5Z 4E6 - Vancouver/CA
  • 8 Ind Program, Canadian Cancer Trials Group, K7L 3N6 - Kingston/CA


Abstract 19O

CFI-402257 is a selective oral inhibitor of TTK protein kinase, a critical regulator of the mitotic spindle assembly checkpoint. TTK is overexpressed in breast cancer (BC); CFI-402257 has anti-proliferative and cytotoxic activity as monotherapy. Synergy has been identified between TTK inhibitors and taxanes; CFI-402257 enhances the antitumor activity of paclitaxel in BC xenograft models.

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