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A first-in-human phase I study of MORAb-202 in patients with folate receptor alpha-positive advanced solid tumors

Date

03 Mar 2020

Session

Proffered Papers 2: Individual targets

Presenters

Jun Sato

Citation

Annals of Oncology (2020) 31 (suppl_1): S8-S10. 10.1016/annonc/annonc82

Authors

J. Sato1, T. Shimizu1, Y. Fujiwara1, K. Yonemori1, T. Koyama1, A. Shimomura1, K. Tamura2, S. Iwasa1, S. Kondo1, K. Sudo1, H. Ikezawa3, M. Nomoto3, R. Nakajima3, T. Miura3, N. Yamamoto1

Author affiliations

  • 1 Department Of Experimental Therapeutics, National Cancer Center Hospital, 104-0045 - Tokyo/JP
  • 2 Department Of Breast And Medical Oncology, National Cancer Center Hospital, 104-0045 - Tokyo/JP
  • 3 Eisai Co. Ltd, 112-8088 - Tokyo/JP
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Resources

MORAb-202 is a novel antibody-drug conjugate consisting of farletuzumab (a humanized monoclonal antibody that binds to folate receptor alpha (FRA)) paired with a cathepsin B-cleavable linker to eribulin. Here we report preliminary results of part 1 (dose escalation part) from a first-in-human phase 1 study of MORAb-202 in patients (pts) with FRA-positive solid tumors.

Resources from the same session

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