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e-Poster Display Session

58P - Real-world data of incidence of immune related toxicities with single agent immuno oncology drugs at a single center

Date

09 Dec 2020

Session

e-Poster Display Session

Topics

Immunotherapy

Tumour Site

Presenters

Goteti Sharat Chandra

Citation

Annals of Oncology (2020) 31 (suppl_7): S1428-S1440. 10.1016/annonc/annonc391

Authors

G. Sharat Chandra1, M. Singhal2, A. Sharma2, S. Valame2, D. Panda2

Author affiliations

  • 1 Medical Oncology, Indraprastha Apollo Hospital, 110076 - New Delhi/IN
  • 2 Indraprastha Apollo Hospital, New Delhi/IN
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Abstract 58P

Background

IO agents have revolutionised the treatment in many solid cancers leading to improved overall survival and also quality of life. Although well tolerated, immune related toxicities have been an issue. Data about the same from the real world practise is little known.

Methods

We aimed to evaluate the toxicity profile of IO agents across different solid cancers at our center .Consecutive patients who were treated with IO regimens between Jan 2018 and Feb 2020 were prospectively analysed for Immune related toxicities .They were graded as per Common Terminology Criteria for Adverse Events and managed as per NCCN guidelines for Immune Related Toxicities .All patients who received at least 2 doses of IO agents were included in the study.

Results

Between Jan 2018 and Feb 2020 ,115 patients were eligible and analysed for immune related toxicities .There were 62 females (53.9%) and 53 males (46.1%) .IO agents used were Nivolumab (n=56) ,Pembrolizumab (n=40) ,Atezolizumab (n=14) and Durvalumab (n=5) .Among different indications ,Metastatic NSCLC (21.7%) ,Bladder (12.1%) ,RCC (12.1%),HCC (11.3%) were most common .Incidence of all grades Immune Related Toxicities was 68.6% (n=79) .Grade ½ was seen in 60% (n=69) and grade ¾ was seen in 8.6%(n=10) .Most common toxicities were Hypothyroidism (35.4%) ,Pneumonitis(20.2%) ,Colitis (12.6%) ,Adrenal (7.5%) ,Hepatic (6.3%) ,Dermatologic (3.7%) ,Renal (3.7%) and Diabetes (3.7%) .Grade ¾ toxicities encountered were Pneumonitis (n=3) ,Colitis (n=2) ,GBS (n=1) ,Nephritis (n=1), Pancreatitis (n=1) ,Hypophysitis (n=1) and Hepatitis (n=1) .Grade 4 toxicity lead to 4 deaths in our study period.

Conclusions

Immune Related Toxicities are as common in the real world as in the trial population often leading to discontinuation of the drug .Our study depicts the incidence of different toxicities encountered with single agent IO drugs at a single center.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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