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e-Poster Display Session

59P - Real-world data of immunotherapy in patients over 65 years old with lung cancer

Date

09 Dec 2020

Session

e-Poster Display Session

Topics

Geriatric Oncology

Tumour Site

Non-Small Cell Lung Cancer

Presenters

Beatriz Nuñez-Garcia

Citation

Annals of Oncology (2020) 31 (suppl_7): S1428-S1440. 10.1016/annonc/annonc391

Authors

B. Nuñez-Garcia, Y. Garitaonaindía Díaz, M. Martinez-Cutillas, M. Blanco, R. Aguado

Author affiliations

  • Puerta de Hierro University Hospital, Madrid/ES
More

Abstract 59P

Background

Immunotherapy (IO) has become one of the leading treatments for advanced lung cancer. The number of elderly patients treated in routine clinical practice contrasts with the low representation of these in clinical trials. The aim of the study is to establish clinical differences between patients older and younger than 65 years treated with IO.

Methods

We conducted a single centre retrospective review including 137 patients treated with IO in Puerta de Hierro University Hospital (Madrid) between 2014 and 2019. We collected information regarding epidemiology, treatments, response and survival patterns and we performed a comparative analysis between patients <65 and ≥ 65 years.

Results

Clinical data, toxicities, treatments and survival are shown in the table. There were no differences in high grade toxicities (9.1% vs 10.4%) or treatment interruption (20.3% vs 17.6%, p=0.576). We didn´t find difference in OS (16.0 vs 17.0) between both groups.

Table: 59P

<65 (69) >65 (68) Long rank (p)
Sex M F 54.5% 45.6% 74.6% 25.4%
Age 58 72
ECOG 0-1 ≥2 93.2% 4.5% 97.0% 3.0%
Histology Adenocarcinoma Squamous Small cell Others 59.1% 27.3% 2.3% 11.4% 56.7% 25.4% 4.5% 13.4%
Toxicity type Asthenia Pneumonitis Thyroid disorders Skin Others 11.4% 14.8% 10.2% 9.1% 24.9% 13.4% 11.9% 11.9% 9.0% 19.5%
Grade 1-2 ≥3 23.8% 9.1% 28.3% 10.4% 0.99
Treatments (CI, 95%)
Median OS 16.0 (9.1-22.9) 17.0 (7.5-26.5) 0.825
1° line
Median PFS 3.0 (0-6.8) 7.0 (1.2-12.8) 0.164
Duration (median) 3.0 3.0
2° line
Median PFS 11.0 (9.6-12.4) 11.0 (5.1-16.9) 0.837
Duration (median) 9.5 4.0
3° line
Median PFS 2.0 (1.2-2.8) 2.0 (0.1-3.9) 0.338
Duration (median) 2.0 2.0

Conclusions

Our results show that IO has an adequate safety profile in patients ≥65 years and survival results are similar to young patients. Therefore, in our opinion, IO represents a valid and safe option for advanced lung cancer treatment in patients ≥65 years.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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