Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

e-Poster Display Session

42P - Pleural effusion is a negative prognostic factor for immunotherapy in non small cell lung cancer (NSCLC): The PLUIE study


09 Dec 2020


e-Poster Display Session


Tumour Site

Non-Small Cell Lung Cancer


Nicolas Epaillard


Annals of Oncology (2020) 31 (suppl_7): S1428-S1440. 10.1016/annonc/annonc391


N. Epaillard1, J.C. Benitez2, T. Gorria3, E. Fabre-Guillevin4, M. Ruidavets5

Author affiliations

  • 1 Oncology, Hopital Européen Georges Pompidou, 94800 - Paris/FR
  • 2 Cancer Medicine, Gustave Roussy Cancer Campus, Villejuif/FR
  • 3 Hospital Clinic, Barcelona/ES
  • 4 Hopital Européen Georges Pompidou, Paris/FR
  • 5 Hospital Clinic y Provincial de Barcelona, Barcelona/ES

Abstract 42P


Pleura is a common site of metastatic involvement in patients (pts) with NSCLC. Pleura is a natural barrier that can limit the penetration and efficacy of immune checkpoint inhibitors (ICI). We aimed to assess the clinical outcome of pleural effusion (PE) in pts with NSCLC and treated with ICI.


Multicentre international retrospective study of pts with NSCLC treated with ICI between November 2012 and 2019. We stratified the population according to PE vs. Non-PE at IO baseline. Primary endpoints were overall survival (OS) and early death rate (EDR). Secondary outcomes were progression free survival (PFS) and disease control rate (DCR). Association between outcomes and PE was evaluated with logistic regression. Univariate and multivariate Cox models were performed for OS and PFS.


538 pts were included: 196 in the PE group and 342 in the non-PE group. In the overall population, median age was 63 years,35% were female, 9% were never smokers and 85% had a non-squamous NSCLC. In the PE group, median age was 65 years, 32% were female, 12% were never smokers and 78% presented a non-squamous NSCLC. ICI was administered in 1st or 2nd line in 66% of pts, in monotherapy in 94%. PE was associated with higher number of metastatic sites (median 3 vs. 2), and worse performance status (PS≥2, 91% vs 81% in non-PE). Overall, the median OS was 9.7 months (mo) (95%CI: 8.0-11.8); 6.3 mo (4.0-8.6) in PE vs. 11.4 mo (9.7-13.8) in the non-PE respectively, p=0.002. Overall, the ED rate was 31.4%; higher in the PE group (38% vs. 27.5%; OR 1.63, 95%CI: 1.13-2.37, p=0.01). The PFS in the PE group was1.8mo (1.7-2.5) vs. 2.3mo (2.0-3.6), p=0.08. After adjustment on PS, liver/intracanial/bone metastasis, immunotherapy line and dNLR, PE remained an independent prognostic factor for OS (HR: 1.38, 95%CI: 1.09-1.74, p=0.007) and PFS (HR: 1.35, 95%CI: 1.09-1.68, p=0.006). DCR was 40% in the PE vs. 52% in non-PE (OR 1.64, 95%CI: 1.14-2.40, p=0.01). Among the PE cohort (n=196), pleural evacuation (n=73 pts, 37%) patients required pleural evacuation was performed (37%); this requirement was associated with more ED (52% vs 31%, p=0.003).


PE is associated with worse prognosis and lower responses to ICI.

Legal entity responsible for the study

The authors.


Has not received any funding.


D. Planchard: Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: AstraZeneca; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Bristol Myers Squibb; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Boehringer Ingelheim; Honoraria (self), Advisory/Consultancy: Celgene; Advisory/Consultancy, Research grant/Funding (self): Daiichi Sankyo; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Eli Lilly; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Merck; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: Novartis; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: Pfizer; Honoraria (self), Advisory/Consultancy, Travel/Accommodation/Expenses: prIME Oncology; Honoraria (self), Advisory/Consultancy, Travel/Accommodation/Expenses: Peer CME; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: Roche; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Samsung; Research grant/Funding (self): MedImmune; Research grant/Funding (self): Sanofi Aventis; Research grant/Funding (self): Taiho Pharma. N. Reguart Aransay: Honoraria (self), Research grant/Funding (self): Pfizer; Honoraria (self), Research grant/Funding (self): Novartis; Honoraria (self), Advisory/Consultancy: BMS; Advisory/Consultancy: Amgen; Honoraria (self), Advisory/Consultancy: Boehringer Ingelheim; Honoraria (self), Advisory/Consultancy: MSD; Honoraria (self), Advisory/Consultancy: Guardant; Honoraria (self), Advisory/Consultancy: AstraZeneca; Honoraria (self), Advisory/Consultancy: Roche; Honoraria (self), Advisory/Consultancy: Lilly; Advisory/Consultancy: TakedA. B. Besse: Research grant/Funding (institution): Abbvie; Research grant/Funding (institution): Amgen; Research grant/Funding (institution): AstraZeneca; Research grant/Funding (institution): BeiGene; Research grant/Funding (institution): Blueprint Medecine; Research grant/Funding (institution): BMS; Research grant/Funding (institution): Boehringer Ingelheim; Research grant/Funding (institution): Celgene; Research grant/Funding (institution): Cristal Therapeutics; Research grant/Funding (institution): Daiichi-Sankyo; Research grant/Funding (institution): Eli Lilly; Research grant/Funding (institution): GSK; Research grant/Funding (institution): Inivata; Research grant/Funding (institution): Ipsen; Research grant/Funding (institution): Ignyta; Research grant/Funding (institution): Janssen; Research grant/Funding (institution): Merck KGaA; Research grant/Funding (institution): MSD; Research grant/Funding (institution): Nektar; Research grant/Funding (institution): Onxeo. L. Mezquita: Advisory/Consultancy, Research grant/Funding (self): Bristol Myers Squibb; Research grant/Funding (self): Boehringer Ingelheim; Research grant/Funding (self): Amgen; Advisory/Consultancy, Travel/Accommodation/Expenses: Roche; Advisory/Consultancy: Takeda; Non-remunerated activity/ies, Mentorship program: AstraZeneca. E. Auclin: Honoraria (self): Sanofi-Genzymes; Travel/Accommodation/Expenses: Mundipharma. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.