Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

e-Poster Display Session

18P - Influence of local immunity on the prognosis of gastric cancer

Date

09 Dec 2020

Session

e-Poster Display Session

Presenters

Gulnoz Khakimova

Citation

Annals of Oncology (2020) 31 (suppl_7): S1417-S1424. 10.1016/annonc/annonc389

Authors

G. Khakimova

Author affiliations

  • Tashkent city oncology center, Tashkent/UZ
More

Abstract 18P

Background

Gastric cancer (GC) takes 5th place among oncology diseases (1,313,000 cases) and 3rd cause of cancer mortality (819,000 deaths) in the world. The cells of the immune system play a key role in the concept of “antitumor immunity”. The variety of subpopulations of these cells, products of their synthesis and pathways of interaction can explain their possible diametrically opposite action: from mechanisms of antitumor protection to stimulation of carcinogenesis. Aim: To study the state of local immunity in patients with gastric cancer.

Methods

From 2017 to 2018, 45 previously untreated patients with gastric adenocarcinoma (25 with stage I–III, 20 with stage IV) received surgical/combined treatment or chemotherapy, respectively. Tumor tissue was taken before treatment. By using flow cytometry there were evaluated the percentage of tumor tissue infiltration by lymphocytes (CD45+CD14-TIL); T cells (CD3+CD19-TIL); B cells (CD3-CD19+TIL); NK cell (CD3- CD16+CD56+TIL); effector cells CD16 (CD16+Perforin+TIL) and CD8 (CD8+Perforin+TIL) with their cytotoxic potential – active CD16TIL and active CD8TIL; subpopulations of regulatory T cells – NKT cells (CD3+CD16+CD56+TIL), regulatory cells CD4 (CD4+CD25+CD127-TIL) and CD8 (CD8+CD11b-CD28-TIL). The prognostic value of immune cells for overall survival (OS) and progression-free survival (PFS) was assessed.

Results

A favorable prognosis factor for PFS in patients with local and locally advanced forms of gastric cancer was an increase in the number of CD3-CD19+TIL (HR 0.862, 95% CI 0.782–0.957, p=0.005), and an unfavorable prognosis was an increase in NK cells; HR 1.382, 95% CI 1.087–1.758, p=0.008. The negative effect of the relative content of NK cells and NKT cells on OS of patients with metastatic gastric cancer noted (HR 1.249, 95% CI 0.997–1.564, p=0.053; HR 1.127, 95% CI 1.025–1.239, p=0.013). At the same time, an increase in the percentage of tumor tissue infiltration by lymphocytes and an increase in the age of patients (HR 1.005, 95% CI 1.002–1.008, p=0.003; HR 1.098, 95% CI 1.031–1.170, p=0.004) reduce the incidence of PFS in patients with metastatic gastric cancer.

Conclusions

Indices of local immunity can serve as additional prognostic factors for gastric carcinoma.

Legal entity responsible for the study

Tashkent City Oncology Center.

Funding

Has not received any funding.

Disclosure

The author has declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.