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e-Poster Display Session

95P - Immune infiltrate in malignant tumors treated with nivolumab and/or ipilimumab

Date

09 Dec 2020

Session

e-Poster Display Session

Presenters

Korinna Joehrens

Citation

Annals of Oncology (2020) 31 (suppl_7): S1452-S1456. 10.1016/annonc/annonc393

Authors

K. Joehrens

Author affiliations

  • Universitaetsklinikum Carl Gustav Carus Dresden, Dresden/DE
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Abstract 95P

Background

In this study, the known components of the different immune responses (TH1, TH2, Treg) as well as the PD-L1 status of the tumor (TC) and immune cells (IC) were evaluated in a collective of malignant tumors treated with nivolumab and/or ipilimumab.

Methods

Forty-two (42) cases of head and neck squamous cell carcinomas (HNSCC), 104 malignant melanomas (MM), and 50 non-small-cell lung cancers (NSCLC) were investigated by immunohistochemistry for CD3, CD4, CD8, T-BET, GATA3, FOXP3, CD20, IRF4, and PD-L1 expression.

Results

The expression of PD-L1 in TCs of HNSCC was similar in patients with progressive disease (PD), stable disease (SD) or partial response (PR), but differed regarding tumor-infiltrating lymphocytes (TIL’s). Patients with SD or PR exhibited more PD-L1 positive TILs (30%) than patients with PD (5% cases). In 9/42 cases TCs expressed GATA3, in these cases the immune infiltrate contained significantly more T-BET expressing T-cells than in the other cases. In 70% of the MM the TCs expressed IRF4 inducing a TH2 response, thus, most of these cases exhibited an immune infiltrate with features of TH2 response. In NSCLC a prominent immune infiltrate of CD20-positive cells at the tumor invasion front was observed in 40/50 cases (88.9%). This can be explained by the fact that the lungs have direct ant intensive contact with pathogens leading to two overlapping immune reactions.

Conclusions

The composition of the immune infiltrate depends on the tumor localization. In HNSCC the predictive value of PD-L1 expression in tumor cells was lower than PD-L1 expression in TILs.

Legal entity responsible for the study

Korinna Joehrens, Ioannis Anagnostopoulos.

Funding

BMS.

Disclosure

K. Joehrens: Research grant/Funding (self): BMS.

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