Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

e-Poster Display Session

56P - Efficacy and safety of nivolumab (Nivo) in recurrent and/or metastatic platinum-refractory squamous cell carcinoma of head and neck (R/M SCCHN): A real-world data study


09 Dec 2020


e-Poster Display Session


Juan José Soto Castillo


Annals of Oncology (2020) 31 (suppl_7): S1428-S1440. 10.1016/annonc/annonc391


J.J. Soto Castillo, J. Esteban Villarrubia, P. Alvarez Ballesteros, P. Garrido Lopez, A. Soria Rivas

Author affiliations

  • Hospital Universitario Ramon y Cajal, Madrid/ES

Abstract 56P


Nivo prolonged overall survival (OS) and was associated with fewer adverse events compared to standard therapy in patients with platinum-refractory R/M SCCHN, as the CheckMate 141 trial showed. Progression-free survival (PFS) improvement is difficult to achieve in this disease, with few additional therapeutic options, as well as symptomatic control, specially in elderly patients (EP) who present significant local morbidity.


We retrospectively reviewed R/M SCCHN patients treated with Nivo (3 mg/kg every 2 weeks) after platinum-based therapy, from March 2017 to August 2020, in our institution. Efficacy (PFS and response rates (RR) of different disease locations) and safety profile (immune-related adverse events (irAEs)) in EP (≥70 yr) were collected. Stata 15.1 was used for the statistic analysis.


Thirty patients were included. Mean age was 66.7 yr (50-89), men represented 73.3% and ECOG 0-1 was present in 93.3%. Tumor primary site was oral cavity 30%, oropharynx 20%, hypopharynx 13.3%, larynx 20% and unknown origin 13.3%. 20% had loco regional disease, 33.3% had distant metastases and 46.6% had both. Nivo constituted the 2nd line of treatment in 90% of patients. Median number of immunotherapy cycles was 9 (3-38). In the overall population, RR was 33.3% (partial response 23.3%, complete response 10%). Median PFS was higher in patients who only had metastatic disease, compared to patients who presented both loco regional and metastatic disease (8.8 vs. 5.1 months). RR was higher in metastatic lesions than in loco regional disease (41.6% vs. 20%). Regarding toxicity, 30% irAEs were reported. There were no statistically significant differences in terms of irAEs incidence between patients <70 and ≥70 yr (38.4% vs. 50%; p = 0.528). Three grade 3-4 irAEs occured (1 G3 gastritis, 1 G4 colitis and 1 G3 psoriasiform disorder). The development of serious irAEs was significantly associated with higher probability of response (100% vs. 30%; p = 0.008).


Our retrospective study suggest that 2nd line therapy with Nivo for R/M SCCHN provide higher RR in metastatic lesions, without increasing toxicity in EP. High-grade irAEs could be a good predictive response factor.

Legal entity responsible for the study

The authors.


Has not received any funding.


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.