Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

e-Poster Display Session

52P - Discontinuation of immune checkpoint inhibitor (ICI) above 18 months of treatment in real-life patients with non small-cell lung carcinoma (NSCLC) : INTEPI, a multicentric retrospective study.

Date

09 Dec 2020

Session

e-Poster Display Session

Presenters

Geoffroy Bilger

Citation

Annals of Oncology (2020) 31 (suppl_7): S1428-S1440. 10.1016/annonc/annonc391

Authors

G. Bilger1, N. Girard1, H. Doubre2, M. Giaj Levra3, E. Giroux-Leprieur4

Author affiliations

  • 1 Institut Curie, Annecy/FR
  • 2 Hopital Foch, Suresnes/FR
  • 3 CHU Grenoble Alpes - Site Nord La Tronche, La Tronche/FR
  • 4 Hopital Ambroise Pare, Boulogne-Billancourt/FR
More

Abstract 52P

Background

The optimal treatment duration of ICIs for patients with NSCLC remains uncertain. In phase 3 clinical trials, treatment continued for 2 years or until disease progression, and results from CheckMate 153 trial suggest to continue beyond 1 year. Real life data are missing.

Methods

This multi-centric retrospective study presents data on real-life patients who discontinued treatment after at least 18 months of ICI monotherapy, their tumour being still controlled. Their characteristics, the causes of discontinuation of ICI, and their outcome are described.

Results

Between July 2015 and May 2018, 107 patients had their tumour controlled after at least 18 months of treatment. Among them, 54 (50%) patients discontinued ICI: 76% male, median age 63, 91% PS 0-1, 54% adenocarcinoma, 20% with brain metastases, PD-L1 expression level available for 18 (33%) patients (2 <1%, 8 btw 1-50% and 8 >50%), 93% treated after 1st line. The median duration of treatment was 26 months. Treatment was stopped by choice of the prescriber and toxicity in 46% and 22% respectively. With a median follow up of 16 months from ICI discontinuation, 14 (26%) patients had a tumour progression with a median time of 9 months (2-33). From discontinuation, overall survival (OS) and progression free survival (PFS) were 90% and 71% respectively at 12 months and 82% and 66% respectively at 24 months. Best tumour response at treatment discontinuation seems to be correlated to duration of disease control, with a PFS rates of 70% for complete response (CR n=11), 77% for partial response (PR n=37), 31% for stable disease (SD n=6), and 76% for CR and/or complete metabolic response with 18F-FDG PET/CT (CMR). Ten patients out of the 14 in the relapse group received a subsequent treatment: 6 were retreated with an anti-PD-1 (with best response 17% PR and 83% SD) and 4 received a localized therapy with 100% CR.

Conclusions

Our study in real life provides new insight into the long-term outcomes of patients treated with ICI for at least 18 months before discontinuation in the absence of PD. CR and CMR with FDG-PET before therapy discontinuation may be a positive factor for a prolonged disease control upon discontinuation.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.