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Lunch & Poster Display session

20P - The immune profiles in young, adult and elderly of advanced stage colorectal cancer patients

Date

12 Dec 2019

Session

Lunch & Poster Display session

Presenters

Ida Bagus Budhi

Citation

Annals of Oncology (2019) 30 (suppl_11): xi1-xi11. 10.1093/annonc/mdz447

Authors

I.B. Budhi1, M. Ida Bagus1, S. Ida Ayu2, I. Darmawan3, S. Widyanti4, Y.Y. Kristanto4

Author affiliations

  • 1 Surgery, Sebelas Maret University, 57126 - Surakarta/ID
  • 2 Surgery, Pendidikan Ganesha University, 81116 - Singaraja Bali/ID
  • 3 Cardiothorasic Surgery, Sebelas Maret University, 57126 - Surakarta/ID
  • 4 Surgical Oncology, Sebelas Maret University, 57126 - Surakarta/ID
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Resources

Abstract 20P

Background

The incidence of colorectal cancer cases is high and increases each year. Colorectal cancer is the 3rd most common cancer in both sexes. The five-year survival rate has not increased significantly for several decades. Usually our patients come to the hospital already in advanced stage and the elderly patients seem to have a better clinical outcome than young and adult patients. One factor that could be suggest for those cases is different immune profiles between them. We evaluated the difference of immune profiles between those groups in advanced stage colorectal cancer.

Methods

This was a cross sectional analytic study on colorectal cancer patients in advanced stage, to evaluate whether any difference in immunity profiles between 3 age groups (young: <40 y.o; adult: 40 – 60 y.o; elderly: >60 y.o). We evaluated the level of CRP, IL-1β, IL-6, IL-10 IFNγ, TNFα, CD-8, IG G and IG M from blood specimens of those colorectal cancer patients. MANOVA test was done to evaluate the level of significance of those differences between each age group.

Results

62 colorectal cancer patients were evaluated on this study. We found significant differences in the levels of CRP, IL-6, IFNγ, CB-8, IG G and IG M between the young, adult and elderly patients, rp < 0.05. Whereas the difference between the young and adult patients, in the levels of IL-6, IFNγ, CD-8, IG G and IG M were found to be significant (p < 0.05), while between the young and elderly group, the signifant differences were in the levels of CRP, IL-6, IFNγ, CB-8, IG G and IG M (p < 0.05). The level of IL-6 was only significantly different between the adult and elderly group (p < 0.05)

Conclusion

There were significant differences in immune profile between young, adult and elderly colorectal cancer patients.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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