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Poster Display session

269 - Signs of immunosenescence in patients diagnosed with non-small cell lung cancer

Date

14 Dec 2018

Session

Poster Display session

Presenters

Teresa Soria Comes

Citation

Annals of Oncology (2018) 29 (suppl_10): x1-x10. 10.1093/annonc/mdy493

Authors

T. Soria Comes1, V. Palomar-Abril1, M. Martin Ureste1, J.E. Marco Buades2, M.J. Fernandez Llavador2, J. Garcia Sanchez1, M.D.C. Cancela Gomez1, I. Maestu Maiques1

Author affiliations

  • 1 Medical Oncology, Hospital Dr. Peset, 46017 - Valencia/ES
  • 2 Hematology, Hospital Dr. Peset, 46017 - Valencia/ES
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Resources

Abstract 269

Background

Lately, there has been a great evolution of immunotherapy in non-small cell lung cancer (NSCLC) due to its relationship with inflammation. There is also a growing interest in the changes produced in immune system with age (immunosenescence). However, it is unclear if these differences also exist among elderly patients with cancer compared to adult patients with the same diagnosis and this is the aim of our study.

Methods

We retrospectively studied patients diagnosed of NSCLC during January-December 2017 at the time of diagnosis, excluding patients with chronic infections or autoimmune diseases. Included cases were divided into two groups depending on age. Lymphocyte count by flow cytometry was gathered at baseline and we studied if there were statistically significant differences in lymphocyte populations between young (<70) and elderly patients (≥70). The non-parametric Mann-Whitney test was used.

Results

81 patients were analysed; 32 in the young group and 49 in the elderly group. Regarding the innate immunity, the median value of NK lymphocytes showed to be higher in the cohort of patients ≥70 years (295 vs 191 cells/mm3; p = 0.0014). Oppositely, the median value of B-lymphocytes was lower in elderly patients (99 vs 128 cells/mm3; p = 0.0282). The Spearman coefficient for the correlation between age and B-lymphocyte count supports this data: ρ = 0.36 (moderate association). However, there was no difference between the median values of T-lymphocytes (p = 0.142). Interestingly, analysing T-lymphocyte subsets we found that median CD8 value was higher in the elderly group (464 vs 309.5 cells/mm3; p = 0.0226) but there was no difference in the CD4-lymphocyte subset (p = 0.4928).

Conclusions

Our results are similar to the ones reported in non-oncologic population, such as an increased number of NK-lymphocytes in elderly patients and a lower count of B-lymphocytes. Therefore, signs of immunosenescence can be seen in patients with NSCLC. However, subpopulations of lymphocytes show more accurately cell functionality. This is why we are performing deeper research regarding the changes in immune system produced with age in oncologic patients.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Doctor Peset University Hospital.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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