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Poster session 01

91P - Liquid biopsy, a tool to detect genetic alterations with therapeutic impact in international patients: Prospective data on 47 patients from Gustave Roussy

Date

10 Sep 2022

Session

Poster session 01

Topics

Molecular Oncology

Tumour Site

Presenters

Tarek Assi

Citation

Annals of Oncology (2022) 33 (suppl_7): S27-S54. 10.1016/annonc/annonc1037

Authors

T.S. Assi1, T. Ibrahim1, C. Chahine1, N. Lezghed1, N. Masri1, E. Rouleau2, O. Caron3, A. Le Cesne1

Author affiliations

  • 1 International Department Of Medical Oncology, Gustave Roussy - Cancer Campus, 94805 - Villejuif/FR
  • 2 Tumor Genetics, Gustave Roussy - Cancer Campus, 94805 - Villejuif/FR
  • 3 Tumor Genetics, Institut Gustave Roussy, 94805 - Villejuif, Cedex/FR
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Abstract 91P

Background

Liquid biopsy (LB), or cell-free DNA analysis (cfDNA), is a novel non-invasive approach to detect molecular alterations (MAs) in cancer patients (pts) allowing personalized therapy. It has been validated in clinical trials, however, the real-world evidence is still in its initial steps. The aim is to evaluate the outcomes of LB in ICP (International cancer pts) with the intention of offering novel treatment options.

Methods

We included in this prospective real-world study pts with advanced solid cancers admitted to the international department of Gustave Roussy starting December 2021. cfDNA was extracted from peripheral blood using streck tubes which were sent to FoundationOne®Liquid CDx for sequencing.

Results

47 pts were included with a median age of 60.5 years. 46.8% (22 pts) were males. Gastrointestinal cancers were the most common neoplasms in 20 (42.5%) followed by thoracic tumors in 9 (19.1%). Pts were from 7 nationalities (29 from Kuwait (61.7%), 11 from Algeria (23.4%), and 7 from other countries (14.9%). 17 were treatment-naïve (36.2%), 34 were previously treated with chemotherapy (73.3%), and 16 (34%) with immunotherapy. On the day of LB, 43 had distant metastases (91.5%) while 24 had an ECOG score of 0-1 (51.1%). Among the 47 pts, 2 (4.2%) had insufficient cfDNA to perform the LB. Median number of MA detected was 5. Tumor mutational burden (TMB) ≥ 10 was found in 7 (14.9%) pertaining an option for immunotherapy. Beyond TMB, 10 MAs were detected with available therapeutic options in 9 (19.1%). The following MAs were confirmed: KRAS G12C (2, lung and pancreatic), EGFR (1, lung), IDH1 (1, cholangiocarcinoma), BRAF (2, angiosarcoma and colon), BRCA2 (1, pancreatic), PIK3CA (2, breast) and FGFR3 (1, bladder). In total, 15 pts with 17 MAs were offered an innovative approach based on LB (31.9%). Also, an additional 22 MAs were detected in 16 pts with available phase I or II clinical trials. A JAK2 mutation was detected in a pt which necessitated hematology referral.

Conclusions

LB proved to be an easy and attractive tool to pinpoint MAs with a significant diagnostic and therapeutic impact. It is an alternative mean to carefully spot MAs in ICP with 31.9% of pts offering them additional therapeutic options.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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