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Poster session 03

851P - Frequency and clinical significance of homologous recombination deficiency gene mutations in non-cutaneous melanoma

Date

10 Sep 2022

Session

Poster session 03

Topics

Population Risk Factor;  Cancer Epidemiology

Tumour Site

Melanoma

Presenters

Yue Yang

Citation

Annals of Oncology (2022) 33 (suppl_7): S356-S409. 10.1016/annonc/annonc1059

Authors

Y. Yang, B. Lian, L. Si, Z. Chi, X. Sheng, Y. Kong, C. Cui, J. Guo

Author affiliations

  • Renal & Melanoma Dept, Peking University Cancer Hospital and Institute, 100142 - Beijing/CN
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Abstract 851P

Background

Homologous recombination deficiency (HRD) refers to the state of tumor cells which received defects in DNA-damage repair mechanisms. The HRD phenotype encodes important proteins for DNA homologous recombination repair (HRR) which can serve as a biomarker of therapeutic efficacy. Here, we explored the frequency and clinical significance of HRD gene mutations in non-cutaneous melanoma to provide experience for clinical options.

Methods

The data of 978 Chinese non-cutaneous melanoma patients using next-generation sequencing techniques with 81 or 425 cancer-related genes were collected. Among them, 881 patients were detected with 81 genes and 97 with 425 genes. The survival analysis was used to find the correlations between HRR gene mutations and clinical outcomes.

Results

In non-cutaneous patients, 10.8% (106/978) patients were found the genomic alterations in HRR genes. The frequently mutated genes were ATM (3.9%), ARID1A (3.8%), BRCA2 (2.8%), BRCA1 (1.5%), BRIP1 (0.4%), ATR (0.1%), PALB2 (0.1%), ARID2 (0.1%), FANCA (0.1%) and RAD50 (0.1%). Among 106 patients with HRR gene mutation, 54.7% were males and 65.4% were under 65 years old. 8.0% (27/335) patients were acral melanoma, 9.6% (40/418) patients with mucosal melanoma, 15.2% (5/33) patients with uveal melanoma and 21.5% (34/158) patients with unknown melanoma. In addition, 28.3% had ulcer in primary sites. 21.7% were in stage IV and 4 patients were with M1a, 1 with M1b, 14 with M1c, 4 with M1d. From January 2008 to January 2022, 29 patients among 106 patients with HRR gene mutation died. The median follow-up time was 32.00 months (95% CI: 27.14-36.86 months) and the median overall survival was not reached. The 1-year, 3-year and 5-year survival rates were 92.8%, 63.8%, 55.6%, respectively.

Conclusions

ATM and ARID1A are the most common genomic alterations with HRR genes and patients with HRR gene mutations maybe get survival benefits from treatment.

Editorial acknowledgement

Legal entity responsible for the study

Peking University Cancer Hospital and Institute.

Funding

National Natural Science Foundation of China, Beijing Municipal Administration of Hospitals Incubating Program, Beijing Municipal Administration of Hospitals’ Youth Programme.

Disclosure

All authors have declared no conflicts of interest.

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