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Mini Oral session: Head & neck cancer

657MO - Effectiveness of geriatric assessment-driven interventions on quality of life for 2 years in older patients with head and neck cancer: Results from the EGeSOR trial

Date

10 Sep 2022

Session

Mini Oral session: Head & neck cancer

Topics

Geriatric Oncology

Tumour Site

Head and Neck Cancers

Presenters

Charlotte Lafont

Citation

Annals of Oncology (2022) 33 (suppl_7): S295-S322. 10.1016/annonc/annonc1056

Authors

C. Lafont1, E. Paillaud2, C. Bertolus3, M. Baron4, P. Caillet2, E. Bouvard5, M. Laurent6, D. Salvan7, L. Chaumette8, L. De Decker Lemarcis9, B. Piot10, B. Barry11, A. Raynaud-Simon12, E. Sauvaget13, A. Minard14, A. Anota15, H. Panjo16, L. Brugel17, F. Canouï-Poitrine1

Author affiliations

  • 1 Santé Publique, Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, France; AP-HP, hôpital Henri-Mondor, Service de Santé Publique, F-94010, Créteil, France, 94010 - Creteil/FR
  • 2 Département De Gériatrie, Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, France; AP-HP, Paris Cancer Institute CARPEM, hôpital Européen Georges Pompidou, département de gériatrie, F-75015 Paris, France, 94010 - Creteil/FR
  • 3 Service De Chirurgie Maxillo-faciale, AP-HP, Sorbonne université, Hôpital Pitié Salpétrière, service de chirurgie maxillo-faciale, F-75013 Paris, France, 75013 - Paris/FR
  • 4 Service De Soins De Suites Et De Réadaptation Gériatrique, AP-HP, Sorbonne université, hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Service de Soins de Suites et de Réadaptation Gériatrique, F-94205 Ivry sur Seine, France, 94205 - Ivry sur Seine/FR
  • 5 Service De Gériatrie, AP-HP, hôpital Tenon, service de gériatrie, F-75020 Paris, France, 75020 - Paris/FR
  • 6 Département De Gériatrie, Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, France; AP-HP, hôpital Henri-Mondor, Département de Gériatrie, F-94010 Créteil, France, 94010 - Creteil/FR
  • 7 Service Orl Et Cervico-facial, Centre Hospitalier Sud Francilien, Service ORL et cervico-facial, F-91100 Corbeil-Essonnes, France, 91100 - Corbeil-Essonnes/FR
  • 8 Service De Court Sejour Gériatrique, Centre Hospitalier Sud Francilien, Service de court sejour gériatrique, F-91100 Corbeil-Essonnes, France, 91100 - Corbeil-Essonnes/FR
  • 9 Service De Gériatrie, Centre Hospitalier Universitaire de Nantes, service de gériatrie, F-44093 Nantes, France, 44093 - Nantes/FR
  • 10 Service De Chirurgie Maxillo-faciale Et Stomatologie, Centre Hospitalier Universitaire de Nantes, service de chirurgie maxillo-faciale et stomatologie, F-44093 Nantes, France, 44093 - Nantes/FR
  • 11 Service Orl Et Chirurgie Cervico-faciale, AP-HP, Université de Paris, hôpital Bichat, Service ORL et chirurgie cervico-faciale, F-75018 Paris, France, 75018 - Paris/FR
  • 12 Service De Gériatrie, AP-HP, Université Paris Cité, hôpital Bichat, service de gériatrie, F-75018 Paris, France, 75018 - Paris/FR
  • 13 Service Orl Et Chirurgie Cervico-faciale, Groupe Hospitalier Paris-Saint Joseph, service ORL et chirurgie cervico-faciale, F-75014 Paris, France, 75014 - Paris/FR
  • 14 Service De Gériatrie, Hôpital Léopold Bellan, Service de gériatrie, F- 75014 Paris, France, 75014 - Paris/FR
  • 15 Clinical Research And Innovation Department & Department Of Human And Social Sciences, Clinical Research and Innovation Department & Department of Human and Social Sciences, Centre Léon Bérard, Lyon, France; French National Platform Quality of life and Cancer, France, 69373 - Lyon cedex/FR
  • 16 Cesp, Université Paris-Saclay, UVSQ, Inserm, CESP, 94807 Villejuif, France, 94807 - Villejuif/FR
  • 17 Service D'orl Et Chirurgie Cervico-faciale, Centre Hospitalier Intercommunal de Créteil, Service d'ORL et Chirurgie Cervico-faciale, F-94010 Créteil, France, 94010 - Créteil/FR
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Abstract 657MO

Background

About 30% of Head and Neck Cancer (HNC) cases are diagnosed in patients aged 70 years and older. Due to their location, HNC and the toxicity of associated treatments may have consequences on quality of life. The aim of this study was to assess the effectiveness of Geriatric Assessment (GA)-driven interventions on quality of life for 2 years in older patients with HNC.

Methods

The EGeSOR study was a two parallel group, multicenter, randomized, controlled and open-label trial, including HNC patients aged 65 years and over between 2013 and 2018. Patients were randomized 1 :1 to receive either a pre-therapeutic GA, a standardized geriatric intervention and follow-up (intervention group) or standard of care (control group). The main outcome was quality of life measures through the European Organisation for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30/100) and HNC questionnaire (QLQ-HN35/100) at 6, 12 and 24 months. Linear mixed models were performed.

Results

Among the 475 patients included (238 in the intervention group and 237 in the control group), the median age was 75.3 years, 31% were women, 44% with oral cancer and 21% metastasis. At baseline, the median score of global health status was 66.7 [50-83.3]. There were no statistically significant differences in evolution between the two groups in either the QLQ-C30 (15 dimensions) or HN35 scores (18 dimensions) over the 24-month period. The evolution of global health status followed a J-shape between M0 and M24 (median gain : 8 points). In the intervention group, 74% of patients did not receive the complete intervention as planned. Statistical analyses regarding age, tumor site and metastasis status are ongoing.

Conclusions

Baseline GA did not improve quality of life for 2 years in older patients with HNC. Difficulties in implementation of complete interventions may have contributed to this result. Alternative models to implement GA-driven interventions could be explored.

Clinical trial identification

NCT02025062.

Editorial acknowledgement

Legal entity responsible for the study

Assistance Publique des Hôpitaux de Paris - APHP.

Funding

The EGeSOR study was supported by grants from the French National Cancer Institute [INCa] [RAFC1202] and the platform for clinical research in older cancer patients (PACAN, Ligue Nationale contre le Cancer).

Disclosure

E. Paillaud: Financial Interests, Invited Speaker, Honoraria for presentation during an educational Symposium: Amgen, Servier; Financial Interests, Advisory Board: Pfizer, BMS; Financial Interests, Other, Supports for participation to congress, travel and inscription from Nutricia. P. Caillet: Non-Financial Interests, Other, Contract as expert in geriatric oncology for an observational prospective cohort (phase IV). No fees: Pfizer; Financial Interests, Invited Speaker, Honoraria for presentation during an educational Symposium: Amgen; Financial Interests, Advisory Board: Pfizer. A. Raynaud-Simon: Financial Interests, Other: Nestlé, Nutricia, Lactalis, Fresenius, Entreprises de la Nutrition Clinique. A. Anota: Financial Interests, Personal, Advisory Board: Roche, AstraZeneca, Sandoz, Amgen, Ipsen; Financial Interests, Personal, Invited Speaker: BMS; Financial Interests, Personal, Other, Travel fees: BMS, AstraZeneca, Novartis; Financial Interests, Personal, Invited Speaker, Travel fees: AstraZeneca. All other authors have declared no conflicts of interest.

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