Abstract 782P
Background
CRS after neoadjuvant chemotherapy (NACT) and gBRCA status predict survival outcomes of women diagnosed with advanced HGSOC. We investigated the correlation between CRS and gBRCA to understand the potential of CRS as an inexpensive biomarker for PARPi therapy.
Methods
Analysis of the OC gBRCA testing database from a tertiary referral centre. Eligible criteria included women with FIGO stage IIIC/IV HGSOC who received NACT and had gBRCA tested between 01/09/2017 and 31/12/2022. Univariable and Multivariable (MV) Cox Proportional-Hazards Models were applied to assess the association between PFS, OS and clinical factors. Two-Proportions Z Test was applied to assess the proportions of CRS1+2 or CRS3 between gBRCA.
Results
536 women were eligible. Mean age 66 years (range 36–89). 139 had FIGO stage IVB HGSOC. 71% received 3-weekly carboplatin with paclitaxel. Median PFS was 14.4 months (95%CI 13.6–15.4) and OS 38.0 months (95%CI 34.8–42.6) in the overall population. Performance status (0–1 vs. 2–4), cytoreductive surgery (Yes vs. No) and gBRCA status (mutant[MT] vs. wild type[WT]) were predictive (PFS) and prognostic (OS) in the overall population (all P<0.05). 363 women underwent delayed primary surgery (DPS) and had a CRS. Of these, 90% received 3–4 cycles of NACT and 96% had optimal (≤1 cm) cytoreduction. In the NACT-DPS group, MV analysis showed that residual disease (≤1 vs. >1 cm), CRS (3 vs. 1+2) and gBRCA status (MT vs. WT) were predictive (PFS) (all P≤0.02). Proportion testing showed women with gBRCA2 were more likely to have CRS3 vs. CRS1+2 than those with gBRCA1 (P=0.008). Women with gBRCA1 (P=0.075) and gBRCA2 (P=0.078) were not more likely to have CRS3 vs. CRS1+2 then those with WT.
Conclusions
We found a correlation between CRS3 and gBRCA2, but not gBRCA1, in women with FIGO stage IIIC/IV HGSOC treated with NACT-DPS. CRS should be evaluated in a prospective study as a predictor of PARPi efficacy.
Table: 782P
CRS | gBRCA1 | gBRCA2 | WT | PFS, months (95%CI) |
1 | 7 | 1 | 60 | 12.1 (11.5–15.7) |
2 | 19 | 9 | 146 | 15.4 (14.4–16.7) |
1+2 | 26 (84%) | 10 (45%) | 206 (66%) | 14.9 (14.0–16.0) |
3 | 5 (16%) | 12 (55%) | 104 (34%) | 22.8 (20.7–27.9) |
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
R.D. Morgan.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
758P - Phase II trial evaluating the efficacy of pembrolizumab combined with vorinostat in patients with recurrent and/or metastatic vulvar and vaginal squamous cell carcinoma: Subgroup analysis of the PEVOsq basket trial
Presenter: Mathilde Saint-Ghislain
Session: Poster session 11
759P - Nimotuzumab combined with concurrent chemo-radiotherapy in patients with locally advanced cervical squamous cell carcinoma: A randomized, controlled, open-label, multicenter study
Presenter: Junjie Wang
Session: Poster session 11
760P - Efficacy and safety of nimotuzumab plus radiotherapy for elderly patients with locally advanced cervical squamous cell carcinoma
Presenter: Ang Qu
Session: Poster session 11
761P - A phase II trial of avelumab in combination with pegylated liposomal doxorubicin in recurrent/metastatic endometrial cancer (GEICO 70-E): analysis according to molecular classification
Presenter: Josep M. Piulats
Session: Poster session 11
764P - Tislelizumab (Anti-PD-1) combined with definitive chemoradiotherapy in recurrent and/or metastatic cervical cancer (PILOT-2020-511): A single-arm, phase II trial
Presenter: JUN ZHU
Session: Poster session 11
765P - SABRINA study: A phase II study of senaparib monotherapy for patients (pts) with BRCA1/2 mutated recurrent platinum-sensitive ovarian cancer (PSOC)
Presenter: Xiaohua Wu
Session: Poster session 11
766P - A comparative study of sequential and interdigitated brachytherapy with chemoradiation in patients of locally advanced carcinoma cervix
Presenter: Shreya Singh
Session: Poster session 11
767P - Phase I/II study of toripalimab with cisplatin-based concurrent IMRT for local advanced cervical cancer
Presenter: Ping Jiang
Session: Poster session 11