Abstract 3769
Background
Lymphocytes are an important portion of the cell-mediated immune system, and play a significant role in immune responses to cancer. We investigated whether peripheral lymphocyte are associated with disease-free survival, gastric cancer-specific survival, and overall survival in surgically resected gastric cancer.
Methods
We retrospectively evaluated stage II-III gastric cancer patients who underwent curative surgical resection to analyze correlations among absolute lymphocyte counts and prognosis. Multivariable regression models adjusted for age, performance status, cancer stage, neoadjuvant/adjuvant chemotherapy use, HER2 expression were used to evaluate associations between absolute lymphocyte count, disease-free survival, gastric cancer-specific overall survival, and overall survival.
Results
A total of 338 stage II-III gastric cancer patients were diagnosed from January 2011 to December 2015. At the time of diagnosis, lymphopenic were 31 (9.1%) and no patients were neutropenic. Nearly one quarter (25.1%) were ever neutropenic (ANC <1.0 K/μL) and nearly half (52.6%) were lymphopenic (ALC <1.0 K/μL) with a mean minimum ALC value of 1.00 K/μL. On multivariable analysis, ever lymphopenia predicted higher recurrence rate [HR = 12.4; 95% CI 4.9-31.3], higher gastric cancer-specific mortality [HR = 22.7; 95% CI 6.5-79.1], and higher overall mortality [HR = 36.6; 95% CI 10.3-130.0]. Five year disease-free survival was 57% for patients who were ever lymphopenic versus 96% for those who were not. Fiver year gastric cancer specific overall survival was 65% versus 98% for ever lymphopenic and never lymphopenic patients, respectively.
Conclusions
Higher peripheral lymphocyte counts predicted lower recurrence rate and better overall survival from potentially curable gastric cancer, suggesting that immune function may enhance the effectiveness of non-advanced gastric cancer treatment.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The author.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
5472 - Early response evaluation and CEA response in patients treated in a Danish randomized study comparing trifluridine/tipiracil (TAS-102) with or without bevazicumab in patients with chemorefractory metastatic colorectal cancer (mCRC)
Presenter: Camilla Qvortrup
Session: Poster Display session 2
Resources:
Abstract
2037 - Updated survival analysis of the randomized phase III trial comparing S-1 versus capecitabine in the first-line treatment of metastatic colorectal cancer (SALTO) by the Dutch Colorectal Cancer Group.
Presenter: Johannes Kwakman
Session: Poster Display session 2
Resources:
Abstract
3053 - JFMC51-1702-C7: Phase II study investigating efficacy and safety of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) in patients (pts) with metastatic colorectal cancer (mCRC) refractory or intolerant to standard chemotherapies.
Presenter: Keisuke Kazama
Session: Poster Display session 2
Resources:
Abstract
3183 - Bevacizumab plus trifluridine/tipiracil in elderly patients with previously untreated metastatic colorectal cancer (KSCC 1602): A single-arm, Phase 2 study
Presenter: Akitaka Makiyama
Session: Poster Display session 2
Resources:
Abstract
3233 - Biweekly TAS-102 and Bevacizumab as a Third-Line Chemotherapy for metastatic colorectal cancer: A Phase II Multicenter Clinical Trial (TAS-CC4 study)
Presenter: Yoichiro Yoshida
Session: Poster Display session 2
Resources:
Abstract
5907 - Liquid biopsy concordance based on clonality and timing of testing in patients with metastatic colorectal cancer
Presenter: Pashtoon Kasi
Session: Poster Display session 2
Resources:
Abstract
1866 - Plasma clearance of RAS mutation under therapeutic pressure is a rare event in metastatic colorectal cancer
Presenter: Emilie Moati
Session: Poster Display session 2
Resources:
Abstract
2312 - High Circulating miR-1247 is a marker for poor prognosis in patients with metastatic colorectal cancer treated with chemotherapy and cetuximab
Presenter: Jakob Schou
Session: Poster Display session 2
Resources:
Abstract
5602 - Clinical relevance of circulating tumor (ct)DNA genotyping for first line cetuximab-based treatment monitoring in metastatic colorectal cancer (mCRC): a prospective multicentric study
Presenter: JOANA Vidal Barrull
Session: Poster Display session 2
Resources:
Abstract
3182 - Clonal hematopoiesis mutations in plasma cfDNA RAS/BRAF genotyping of metastatic colorectal cancer
Presenter: Beili Wang
Session: Poster Display session 2
Resources:
Abstract