Abstract 3683
Background
The impact of radiotherapy (RT) on the efficacy and toxicity of immune checkpoint inhibitors in patients (pts) with metastatic non-small cell-lung cancer (NSCLC) is unclear.
Methods
We retrospectively identified pts with metastatic NSCLC treated with the anti-programmed death 1 (PD-1) antibodies nivolumab or pembrolizumab between January 2016 and May 2019 at two major oncology centres in Melbourne, Australia. Patient demographics, tumour characteristics, treatment history including radiotherapy (RT) use and toxicity were collected. Disease control rate (DCR), progression free survival (PFS) and overall survival (OS) were analysed and correlated with RT use.
Results
132 pts identified with interim analysis of 54 reported here. Median follow up was 19.4 months. Majority were male (61%) and 87% were smokers. 80% had non-squamous histology, of these 9% had an EGFR mutation. Brain metastases were present in 41%. The median number of cycles of anti-PD1 treatment received was 5 and only 7% started anti-PD-1 as first-line therapy. 36% received RT treatment either during or within 3 months of starting anti-PD1 treatment. Of patients that received RT, 74% were treated with extra-thoracic RT. The use of RT before or during anti-PD1 treatment did not result in an increase in high grade immune-related adverse events. The DCR was 35%. The median PFS was 2 months (95% CI 0.5 – 29) and OS 9.7 months (95% CI 1.0 – 31). Pts who received RT had a numerically shorter PFS than those that did not (1.5 vs 2 months, p = 0.668) but numerically longer OS (8.1 vs 7.2 months, p = 0.857). Updated analysis with the full cohort and with longer follow-up will be presented.
Conclusions
Radiotherapy did not significantly impact on survival in pts with metastatic NSCLC treated with anti-PD1 therapy.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
5995 - Invasive fungal diseases caused by rare pathogens in patients after hematopoietic stem cell transplantation (HSCT) & chemotherapy
Presenter: Yuliya Rogacheva
Session: Poster Display session 1
Resources:
Abstract
2961 - Safety and pharmacokinetics of novel CXCR4 antagonist YF-H-2015005 in the mobilization of hematopoietic stem cells in patients with non-Hodgkin's lymphoma
Presenter: Weiping Liu
Session: Poster Display session 1
Resources:
Abstract
5771 - Chemotherapy associated Hyponatremia in Hematological Malignancies: A retrospective study of 189 patients treated in a single medical center
Presenter: Vadim Lesan
Session: Poster Display session 1
Resources:
Abstract
1165 - Risk factors for Bacteremia-Associated Mortality of Aeromona sobria in Hematologic Malignancies
Presenter: Gabriel De la Cruz-Kú
Session: Poster Display session 1
Resources:
Abstract
5287 - Use of droplet digital polymerase chain reaction for detecting minimal residual disease: a prospective, multi-institutional study
Presenter: Hyunkyung Park
Session: Poster Display session 1
Resources:
Abstract
1886 - RUBIH2 — Use of NGS in haematological malignancies: from real world data to national recommendations, an innovative program to evaluate the impact of healthcare technology on patient care
Presenter: Severine Coquerelle
Session: Poster Display session 1
Resources:
Abstract
1940 - Outcomes of chronic myeloid leukemia with T315I mutation in the absence of targeted therapy or hematopoietic stem cell transplantation
Presenter: Nageswara Palukuri
Session: Poster Display session 1
Resources:
Abstract
1946 - Is bone marrow examination indispensible in chronic myeloid Leukemia at diagnosis ?
Presenter: Nageswara Palukuri
Session: Poster Display session 1
Resources:
Abstract
1904 - Incidence of Imatinib Resistance in Chronic Myeloid Leukemia (CML) Patients: Experience from Resource Poor Centre of Eastern India
Presenter: Debmalya Bhattacharyya
Session: Poster Display session 1
Resources:
Abstract
3245 - BCR-ABL transcript variant’s significance in chronic myeloid leukemia in chronic phase: Institutional experience from a developing country
Presenter: Siva Prasad
Session: Poster Display session 1
Resources:
Abstract