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Poster Display session

115P - Geriatric breast cancer- Does age matter?

Date

04 May 2022

Session

Poster Display session

Presenters

Talluri Surya

Citation

Annals of Oncology (2022) 33 (suppl_3): S175-S183. 10.1016/annonc/annonc891

Authors

T.S.H.V. Surya1, S.V.S. Deo1, D.N. Sharma1, A. Gogiya1, S. Bhoriwal2, A. MISHRA1

Author affiliations

  • 1 AIIMS - All India Institute of Medical Sciences, New Delhi/IN
  • 2 AIIMS - All India Institute of Medical Sciences, 110029 - New Delhi/IN
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Abstract 115P

Background

The management of breast cancer in elderly patients poses a complex array of challenges due to comorbid illnesses, poor functional status, social issues. There is a paucity of breast cancer data in geriatric patients from developing countries.

Methods

We analyzed the prospectively maintained, computerized breast cancer patient database in the department of surgical oncology. We included the breast cancer patients treated from January 1994 to December 2019. We considered the age at diagnosis of greater than or equal to 65 years to define Geriatric breast cancer (GBC) and analyzed the demography, clinical presentation, stage, histology, molecular subtypes, treatment details, survival outcomes and relapse patterns in these patients.

Results

We identified 4628 breast cancer patients treated during the study period. Of them, 499 ( 10.78%) were Geriatric breast cancer patients. The mean age in this subset was 70.10 years, and 96.99% of patients were females. 330 patients (66.13 %) were between 65 to 70 years, and 3.0% were above 80 years. 49.8 % presented with early breast cancer and 4.6% had stage IV disease. Infiltrative ductal carcinoma was the most common histological subtype (88.7%). 41.4% of patients had luminal-A molecular subtype and 20% were triple-negative. The majority (84.0%) of patients underwent surgery first, mostly mastectomy and the breast conservation rate was 8.6%. The chemotherapy utilization rate was 28.2%, while 32.4% of patients received adjuvant radiotherapy. All luminal subtype patients received adjuvant hormonal therapy. Overall relapse rate was 16.2% (loco-regional relapse-6.2%; systemic relapse -10%). The most common site of systemic recurrence was bone, followed by lung, liver and brain. The 5-year overall survival (OS) and 5-year disease-free survival was 79.8% and 70.8%, respectively.

Conclusions

Geriatric breast cancer comprised 10.7 % of all breast cancers in the current study. Most patients presented between 65-70 years and mainly underwent an upfront mastectomy. With meticulous management in a multi-disciplinary setting, a 5-year OS of 79.8% can be achieved.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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