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Non-vigorous physical activity and the risk of breast cancer among Nigerian women

Date

03 May 2019

Session

Poster lunch

Presenters

Samuel Azubuike

Citation

Annals of Oncology (2019) 30 (suppl_3): iii47-iii64. 10.1093/annonc/mdz100

Authors

S.O. Azubuike1, L. Hayes2, R. McNally2

Author affiliations

  • 1 Institue Of Health And Society, Newcastle University, NE2 4AX - Newcastle upon Tyne/GB
  • 2 Institute Of Health Society, Newcastle University, Newcastle upon Tyne/GB
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Background

Breast cancer incidence in Nigeria has risen by > 120% since 2000. Its mortality rate (18.8 / 100 000 women / year) ranks highest in Africa. Studies have suggested that non-vigorous physical activity is associated with reduced risk of breast cancer. However, its role in breast cancer risk is yet to be established in sub-Saharan Africa. Increasing prevalence of behaviours associated with reduced non-vigorous physical activity has been reported across several countries in sub-Saharan Africa, including Nigeria. The purpose of this study was to investigate if there is an association between non-vigorous physical activity and breast cancer risk among Nigerian women.

Methods

The study was a multisite hospital based case-control design involving 379 histologically confirmed breast cancer cases and 403 controls. The participants were interviewed in-person between October 2016 and May 2017. Cases were selected from the oncology wards and controls from ophthalmology wards. Self-reported non vigorous physical activity (sum of occupational, household and transport physical activities) was summarised as both hours per week and metabolic equivalents hours per week (MET-hr / wk). Data were analyzed using multivariable logistic regression, adjusting for known confounders.

Results

The result (in MET-hr/wk) showed a 40% [95 % confidence interval (CI): 0.40 - 0.89, p for trend = 0.032] reduction in breast cancer risk among women in the upper tertile of total non-vigorous physical activity compared to those in the lowest tertile of non-vigorous physical activity. This was stronger among younger [ odds ratio (OR) 0. 54, 95 % CI: 0.32 - 0.92], premenopausal (OR 0.46, 95% CI: 0.24 - 0.89) and lean women (OR 0.47; 95% CI: 0.25 - 0.88) compared to older, postmenopausal and overweight/obese women respectively.

Conclusions

Non-vigorous physical activity was associated with reduced risk of breast cancer among Nigerian women. This risk reduction was modified by age, menopausal status and body mass index. Conditions that promote increased participation in non-vigorous physical activity among women should therefore be encouraged with respect to breast cancer prevention in Nigeria.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Samuel Onyinyechukwu Azubuike.

Funding

National Open University of Nigeria.

Disclosure

All authors have declared no conflicts of interest.

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