910 - The National Liver Disease Biobank: A Good Resource for Liver and Associated Cancer Research

Background

Liver cancer is the fifth commonest cancer. As per the World Health Organization liver disease is the tenth most common cause of death in India. Among all liver cancers, Hepatocellular carcinoma (HCC) is the most frequent cause and comprises 90% of liver cancer. Liver cancer is one of the leading causes of death worldwide due to its aggressive nature and poor survival rate. Due to the advancement of new technologies, the demand of high quality of biological samples has increased for translational research and drug discovery. Biobank are a suitable place to get a high quality of annotated biosamples. Biobank are playing important role in the field of cancer research, diagnosis, prognosis, and treatment. Most of the Biobank are situated in economically developed countries while cancer and other related disease are more in developing countries. The Indian government has established a world-class National Liver Disease Biobank in 2017 with a capacity of 5.4 million samples. Its aim is to accelerate research and personalized treatment in India.

Methods

The Biobank has collaboration with different hospitals from all over India. It is following Decentralized collection, centralized storage, and informatics. All centers are collecting biosamples as per SOPs of National Liver Disease Biobank.

Results

The Biobank collects, process and store a wide array of biospecimens (tumor tissue, adjacent normal tissue, blood, plasma, serum, buffycoat……) using validated SOPs. At present Our Biobank has collaboration with three hospitals and four research centers. It has collected 2566 biosamples and has involved in many research projects.

Conclusions

Establishment of the biobank is a major step in liver cancer related clinical and basic research in India The aim of NLDB Biobank is to accelerate HCV, liver disease, and associated cancer research. It is a first and biggest Liver Biobank in India, have a network from different hospitals across the country. We have been involving in many research projects which results would be highly useful in patient care and cancer research, biomarker discovery and translational research.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

National Liver Disease Biobank.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.