Neuroblastoma represents 7.8% of all cancers in children in the United States, with more than 600 new cases are diagnosed annually. The incidence of the disease differs according to age, race and primary site. We conducted this study to identify the survival pattern of neuroblastoma arising from different primary sites.
Using the SEER database, we extracted the data of 1336 patients with neuroblastoma from 2000 to 2010, age less or equal to 10 years old. We selected neuroblastoma arising from the adrenal gland, peripheral nerves&autonomic nervous system, mediastinum, and peritoneum.
Adrenal gland was the most frequent primary site for neuroblastoma to occur, with 819(61.3%) documented cases. Better outcomes were observed in children younger than 1 year of age (91.4%), those of a white race (74.6%), and those with tumors arising from the mediastinum (87.7%). However, we found no significant difference in overall survival between males and females.
|Age 00 1-2 3-10||91.4% 68.7% 53.2%||0.000**|
|sex Male female||72.6% 72.8%||0.607|
|race White black Others||74.6% 66.3% 63.5%||0.007*|
|primary site adrenal gland retro-peritoneum mediastinum peripheral nerves/ANS||67.9% 72.3% 87.7% 82.2%||0.000**|
Significant p-value at ≤ 0.001**
Highly significant p-value at ≤ 0.001 ANS: autonomic nervous system
Children younger than 1year, of a white race, and/or with tumor arising at the mediastinum had better 5-year overall survival.
Clinical trial identification
Legal entity responsible for the study
Has not received any funding.
All other authors have declared no conflicts of interest.