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Poster display - Cocktail

663 - STING, an immune biomarker for colorectal cancer

Date

24 Nov 2018

Session

Poster display - Cocktail

Topics

Translational Research

Tumour Site

Colon and Rectal Cancer

Presenters

Hongjae Chon

Citation

Annals of Oncology (2018) 29 (suppl_9): ix28-ix45. 10.1093/annonc/mdy431

Authors

H. Chon, D.J. Kim, C. Kim

Author affiliations

  • Medical Oncology, bundang CHA hospital, 13496 - Seongnam/KR
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Resources

Abstract 663

Background

STING is an innate immune sensor for cytosolic DNA. The activation of STING signaling is indispensable in Type I interferon response and the evocation of anti-cancer immune response by CD8+ T cells. The aim of this study is to characterize intratumoral STING expression pattern and its clinical implication in colorectal cancer (CRC).

Methods

We analyzed STING and CD8 expression in 225 CRC patients who underwent surgical resection. Clinicopathological variables and survival outcomes were analyzed according to STING expression level.

Results

Distinct STING expression was observed in tumor specimens of CRCs. Patients with higher STING expression seemed to have early stage cancer (P = 0.001) with increased intratumoral CD8+ T cell infiltration (P < 0.001), and less frequent lymphovascular invasion (P = 0.02). Compared to CRC patients with lower STING expression, those with higher STING expression had longer overall survival (P < 0.001) and recurrence-free survival (P < 0.001). The Cox proportional hazard model adjusted for age, stage, and CD8+ T cells, revealed that higher STING expression is an independent prognostic factor for a better overall survival (P = 0.012, hazard ratio 0.573, 95% CI 0.370 – 0.886).

Conclusions

We have confirmed the distinct STING expression in CRC and demonstrated its independent prognostic value for the survival outcome, thereby suggesting the intratumoral STING expression as a potential immune biomarker for CRC.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Hongjae Chon.

Funding

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the the Ministry of Science, ICT & Future Planning (grant NRF-2016R1D1A1B03934012 to H.C.).

Disclosure

All authors have declared no conflicts of interest.

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