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Poster display - Cocktail

563 - Role of consolidative radiation therapy after surgery in patients with stage IV rectal cancer

Date

24 Nov 2018

Session

Poster display - Cocktail

Topics

Radiation Oncology

Tumour Site

Colon and Rectal Cancer

Presenters

Tahir Mehmood

Citation

Annals of Oncology (2018) 29 (suppl_9): ix28-ix45. 10.1093/annonc/mdy431

Authors

T. Mehmood

Author affiliations

  • Radiation Oncology, Northwest General Hospital and Research Centre, 13014 - Peshawar/PK
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Resources

Abstract 563

Background

Radiotherapy (RT) and surgery are known to effectively palliate many symptoms of patients with metastatic rectal cancer (mRC). However, whether RT would provide survival benefit to mRC after surgery remains unclear.

Methods

A retrospective population-based cohort study was performed using the Surveillance, Epidemiology, and End Results Program (SEER) database. Patient demographics between the RT and no-RT groups were compared using Pearson Chi-Square tests. Propensity score (PS) matching and Cox proportional hazards regression analyses were performed to evaluate prognostic power of variables on cause-specific survival (CSS).

Results

A total of 5520 mRC patients who have received surgery were identified in SEER database. Multivariable Cox regression analyses showed that RT was a protective factor of mRC patients after surgery in mRC patients (hazard ratio [HR] = 0.654, 95% confidence interval [CI] = 0.607-0.704, p < 0.001). PS matching produced 3887 mRC patients and univariable Cox regression analyses indicated that RT was associated with a significant improvement of CSS in mRC patients after surgery (HR = 0.455, 95%CI=0.422-0.491).

Conclusions

Using SEER database, we have identified that RT was associated with a significant survival advantage in the setting of mRC patients after surgery. This study strongly supports the use of RT after surgery for patients with mRC. In order to accurately define the role of RT in the comprehensive treatment for mRC patients, more prospective studies are clearly needed to be conducted.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

NWGH.

Funding

Has not received any funding.

Disclosure

The author has declared no conflicts of interest.

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