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Poster display - Cocktail

1306 - Poor-prognosis Locally Advanced Rectal Cancer is Defined by a Molecularly Distinct Subtype

Date

24 Nov 2018

Session

Poster display - Cocktail

Topics

Pathology/Molecular Biology

Tumour Site

Colon and Rectal Cancer

Presenters

Jing Zhang

Citation

Annals of Oncology (2018) 29 (suppl_9): ix28-ix45. 10.1093/annonc/mdy431

Authors

J. Zhang, L. Shen, Y. Wang, Y. Deng, L. Yang, J. Wan, Z. Zhang

Author affiliations

  • Radiation Oncology, Shanghai Cancer Center Fudan University, 200032 - Shanghai/CN
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Resources

Abstract 1306

Background

TNM stage is still the only prognostic tool used in clinical practice to treat patients but it fails to accurately predict outcomes. Categorization of locally advanced rectal cancers into distinct subtypes using a combination of qPCR-based biomarkers could provide insight into variability in outcomes.

Methods

We used a PCR-based assay to detect 30 genes (LARCassigner-30) in 197 locally advanced rectal cancer samples, collected prospectively from patients treated with neoadjuvant chemoradiation and surgery from January 2007 to December 2012 in Fudan University Shanghai Cancer Center. 197 patients were randomly divided into training queuing of 98 cases and validation of the cohort of 99 cases. Median follow-up time is 58 months. Association with 5-year overall survival, disease-free survival, recurrent rate and metastatic rate was evaluated using Cox proportional hazards models.

Results

Baseline clinical characteristics and postoperative pathological features were similar between the training cohort and the validation cohort. The overall survival rate of LARCassigner-30 type 1 patients was lower than that of type 2 patients in the training and validation cohorts (p < 0.01), tumor-free survival rate decreased (p < 0.01); local recurrence rate increased (p < 0.01), distant metastasis rate increased (p < 0.01), the difference was statistically significant. In the training cohort, LARCassigner-30 type 1 patients with locally advanced rectal cancer were found to have poorer response to neoadjuvant chemoradiation than type 2 patients (p = 0.023), but they were not verified in the validation cohort.

Conclusions

We developed qPCR-based classifiers LARCassigner-30 that performs well at predicting the outcomes in locally advanced rectal cancer.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Institutional Review Board of Fudan University Shanghai Cancer Center.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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