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Poster display - Cocktail

617 - Osimertinib in the Treatment of Leptomeningeal Disease in T790M-negative, EGFR-mutated NSCLC: A Case Report


24 Nov 2018


Poster display - Cocktail


Cytotoxic Therapy;  Targeted Therapy

Tumour Site


Lawrence Kasherman


L. Kasherman1, J. Chen2, H. Soudy1

Author affiliations

  • 1 Medical Oncology, St George Hospital, 2217 - Kogarah/AU
  • 2 Medical Oncology, St George Hospital, Kogarah/AU


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Abstract 617

Case Summary

Leptomeningeal carcinomatosis (LMC) is a terminal event in advanced cancer, its incidence in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is increasing due to recent advances in systemic therapy and prolongation of survival.

Osimertinib is a third generation EGFR-tyrosine kinase inhibitor (TKI) with preclinical and early clinical studies showing activity against LMC resistant to previous TKI treatments and acquired T790M mutation.

We report a case of osimertinib in the treatment of LMC in a T790M-negative, EGFR-mutated NSCLC with significant clinical benefit and no toxicity.

Osimertinib is a potentially effective treatment for LMC associated with EGFR-mutated NSCLC regardless of T790M status and a well-tolerated treatment for poor performance status patients.

Editorial acknowledgement

Clinical trial identification

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