Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display - Cocktail

611 - Induction chemoradiation therapy in recurrent locally advanced urachal cancer

Date

24 Nov 2018

Session

Poster display - Cocktail

Topics

Radiation Oncology

Tumour Site

Presenters

Thanate Dajsakdipon

Authors

T. Dajsakdipon1, S. Worawichawong2, C. Leenanupunth3, P. Phichai Chansriwong1

Author affiliations

  • 1 Department Of Medicine, Ramathibodi Hospital, 10400 - Bangkok/TH
  • 2 Department Of Pathology, Ramathibodi Hospitol, 10400 - Bangkok/TH
  • 3 Department Of Surgery, Ramathibodi Hospital, 10400 - bangkok/TH

Resources

Login to access the resources on OncologyPRO.

If you do not have an ESMO account, please create one for free.

Abstract 611

Case Summary

A 61-year-old man, presented with painless gross hematuria and palpable mass at suprapubic area. Computed tomography (CT) of abdomen showed enhancing mixed solid-cystic mass size 4 x 3.6 cm originating at the right anterior dome of bladder. He underwent exploratory laparotomy with partial cystectomy with urachal excision. Histopathology reported adenocarcinoma, margin is not free. Immunohistochemistry staining showed positive CK20, CDX2, focally positive CK7 and negative PSA. He was diagnosed with urachal carcinoma stage IIIA by Sheldon et al. classification. That time he did not received any adjuvant chemotherapy and radiotherapy. Five months later, he developed recurrent suprapubic area mass and painless gross hematuria. His physical examination of abdomen showed palpable lobulated fixed hard consistency mass at dome of bladder to lower midline of abdomen. CT of abdomen showed enhancing nodule at the left anterior-inferior aspect of the bladder, and hypodense lesion on midline surgical scar at lower abdomen. He was diagnosed with recurrent locally advanced urachal carcinoma stage IIIB. He was treated by pre-operative concurrent chemoradiotherapy(CCRT) with 5-Flurouracil(5FU) with 350 mg/m2day 1-5 and day 28-33. CT of the abdomen after completion of CCRT showed decreasing size of nodular thickening at the left anterolateral aspect of bladder from 2.8 cm to 1.3 cm (17.8%), no substantial change in size of enhancing soft tissue mass on midline surgical scar. Then he was treated with exploratory laparotomy with tumor removal and partial cystectomy. Histopathology showed adenocarcinoma with mucin production, margin is not free. Multidisciplinary team decided to treat with adjuvant chemotherapy with 5FU-based regimen.

Urachal cancer is a very rare cancer carrying poor prognosis in genitourinary tract cancers. It may present with different clinical manifestations, including an abdominal mass, hematuria and pain. Surgical resection is a main strategy for treatment. There has been no standard regimen for neoadjuvant or adjuvant chemotherapy and radiotherapy. This case showed a favorable response from induction CCRT with 5-FU following by surgery in locally advance urachal adenocarcinoma.

Editorial acknowledgement

Clinical trial identification

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.