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Poster display - Cocktail

662 - Clinical Outcomes in Non–Small Cell Lung Cancer Patients with Ultra-high Expression of Programmed Death Ligand-1 Treated with Pembrolizumab as First-line Therapy: A Retrospective Multicenter Cohort Study

Date

24 Nov 2018

Session

Poster display - Cocktail

Topics

Targeted Therapy;  Immunotherapy

Presenters

Hiroyuki Kurebe

Citation

Annals of Oncology (2018) 29 (suppl_9): ix150-ix169. 10.1093/annonc/mdy425

Authors

H. Kurebe1, R. Edahiro1, M. Kanazu1, D. Fujimoto2, M. Tamiya3, A. Tamiya4, H. Suzuki5, K. Hirano6, T. Yokoyama7, M. Morita8, Y. Fukuda9, J. Uchida10, T. Makio11

Author affiliations

  • 1 Thoracic Oncology, Toneyama National Hospital, 560-8552 - Toyonaka/JP
  • 2 Department Of Respiratory Medicine,, Kobe City Medical Center General Hospital, Kobe/JP
  • 3 Department Of Thoracic Oncology, Osaka International Cancer Institute, Osaka/JP
  • 4 Department Of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center,, Osaka/JP
  • 5 Department Of Thoracic Oncology, Osaka Habikino Medical Center,, Osaka/JP
  • 6 Department Of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki/JP
  • 7 Department Of Respiratory Medicine, Kurashiki Central Hospital, Kurashiki/JP
  • 8 Department Of Respiratory Medicine, Kobe City Medical Center West Hospital, Kobe/JP
  • 9 Department Of Respiratory Medicine, Himeji Medical Center, Himeji/JP
  • 10 Department Of Respiratory Medicine, Osaka General Medical Center, Osaka/JP
  • 11 Department Of Respiratory Medicine, Itami City Hospital, Itami/JP
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Resources

Abstract 662

Background

Pembrolizumab is currently approved for advanced non-small cell lung cancer (NSCLC) patients with programed death ligand-1 (PD-L1) expression ≥50% as first-line therapy. However, the efficacy or immune-related adverse events (irAEs) are unclear in patients with ultra-high PD-L1 expression.

Methods

We retrospectively analyzed patients with advanced NSCLC and PD-L1 tumor proportion score (TPS) of ≥ 50% who received pembrolizumab as first-line therapy at 11 institutions in Japan between February 2017 and January 2018. Patients were separated to TPS 50-74% cohort and TPS ≥75% (ultra-high PD-L1 expression) cohort. Early irAEs were defined as irAEs that occurred within 3 weeks after commencing pembrolizumab therapy.

Results

In total, 161 patients were included; 70 patients in TPS 50-74% cohort and 91 patients in TPS≥75% cohort. The patient characteristics and the frequency of irAEs were not different between both cohorts. The objective response rates (ORR) and disease control rates (DCR) were 54.3% (38/70) and 77.1% (54/70) in TPS 50-74% cohort, 47.3% (43/91) and 69.2% (63/91) in TPS≥75% cohort (P = 0.43, P = 0.29, respectively). Time to treatment failure (TTF) curve showed that TTF of TPS≥75% cohort was comparable to that of TPS 50-74% cohort within 4 months (hazard ratio [HR] = 1.19, 95% confidence interval [CI], 0.74-1.91; P = 0.47). However, TTF of TPS≥75% cohort showed the tendency to be longer in late phase (4 months or later) (HR = 0.48, 95% CI, 0.19-1.25; P = 0.13). In the patients who achieved complete response or partial response, TTF of TPS≥75% cohort was longer than that of TPS 50-74% (HR = 0.49, 95% CI, 0.23-1.03; P = 0.059). The medians of overall survival were not reached in both cohorts. The follow-up is ongoing.

Conclusions

The ORR and DCR of TPS≥75% cohort were comparable to those of TPS 50-74% cohort. However, the patients with ultra-high PD-L1 expression could continue pembrolizumab therapy long when they achieved objective responses.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Masaki Kanazu.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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