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Poster display - Cocktail

1166 - Association of MTHFR gene polymorphisms with glioma and meningioma patients in Indian population


24 Nov 2018


Poster display - Cocktail


Translational Research

Tumour Site

Central Nervous System Malignancies


Rajani Kumawat


Annals of Oncology (2018) 29 (suppl_9): ix21-ix22. 10.1093/annonc/mdy429


R. Kumawat1, S.H. Gowda1, E. Debnath1, S. Rashid1, R. Niwas2, A. Suri3, C. Sarkar4, S. Sinha1, K. Chosdol1

Author affiliations

  • 1 Dept. Of Biochemistry, All India Institute of Medical Sciences, 110029 - Delhi/IN
  • 2 Dept Of Pulmonary And Critical Care Medicine, Vmmc& Safdarjung Hospital, Vardhaman Mahavir Medical College & Safdarjung Hospital, 110049 - New Delhi/IN
  • 3 Dept. Of Neurosurgery, All India Institute of Medical Sciences, 110029 - Delhi/IN
  • 4 Dept. Of Pathology, All India Institute of Medical Sciences, 110029 - Delhi/IN


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Abstract 1166


Brain tumor is a leading cause of death in India. Folate deficiency has been implicated in the etiology of brain tumor through abnormal DNA methylation and polymorphism. The present study was aimed to identify the association of Methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphism with brain tumor in Indian subjects.


Current study includes 288 brain tumor cases (Glioma=108 and Meningioma=76) and 104 healthy control subjects. Genomic DNA isolation was done using Qiagen Puregene Blood Core kit following the manufacturer’s protocol. PCR-RFLP and ARMS-PCR (Amplification Refractory Mutation System) were used to investigate the substitution of MTHFR C677T and A1298C genes respectively.


The major genotype observed for MTHFR C677T was CC genotype in both controls (71.2%) and cases (glioma 73.1%, meningioma 75%) followed by CT genotype (control 25%, glioma 24.1% and meningioma 19.7%) and TT genotype (control 3.8%, glioma 2.8% and meningioma 5.3%). For MTHFR A1298C, AC was the major genotype in both control (50%) and cases (glioma 60.2%, meningioma 48.7%) followed by AA genotype (control 25%, glioma 22.2% and meningioma 36.8%) and CC genotype (control 25%, glioma 17.6% and meningioma 14.5%). In MTHFR A1298C, CC genotype was observed to have reduced risk of having meningioma than AA genotype (OR = 0.62, 95%CI 0.32-0.97, p = 0.03).


Our findings revealed the significant association between polymorphism of MTHFR A1298C genes of folate metabolizing enzymes with glioma/meningioma patients. Further large pool studies are needed to confirm our findings.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Kunzang Chosdol.


Has not received any funding.


All authors have declared no conflicts of interest.

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