Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display - Cocktail

954 - A pilot case-control study of second or third line treatment with cetuximab-containing chemotherapy (Cetux-chemo) in patients (pts) with metastatic colorectal cancer (mCRC) who were previously treated with Cetux-chemo


24 Nov 2018


Poster display - Cocktail


Cytotoxic Therapy;  Targeted Therapy

Tumour Site

Colon and Rectal Cancer


Cheuk Sang Ho


Annals of Oncology (2018) 29 (suppl_9): ix28-ix45. 10.1093/annonc/mdy431


C.S. Ho1, A.C. Cheng2, L. Li3, W.M. Ho3, E.P. Hui4, K.F. To5, J.H.M. Tong6, B.B.Y. Ma4

Author affiliations

  • 1 Faculty Of Medicine, The Chinese University of Hong Kong, NT - Shatin/HK
  • 2 Clinical Oncology, Princess Margaret Hospital, 000 - Kowloon/HK
  • 3 Clinical Oncology, Prince of Wales Hospital, NT - Shatin/HK
  • 4 Clinical Oncology, The Chinese University of Hong Kong, Shatin/HK
  • 5 Department Of Anatomic And Cellular Pathology, The Chinese University of Hong Kong, Shatin/HK
  • 6 Anatomical And Cellular Pathology, Prince of Wales Hospital, NT - Shatin/HK


Login to access the resources on OncologyPRO.

If you do not have an ESMO account, please create one for free.

Abstract 954


This study hypothesized that: (1) pts who had prior exposure to Cetux-chemo in the treatment of mCRC followed by a chemo-break, would respond to re-treatment with Cetux at progression (PD), & that the overall response rate (ORR) would be better than those who are treated with chemo alone.


This study consisted of 2 cohorts. Cohort 1: Prospectively enrolled pts with KRAS-wild type mCRC who had prior Cetux-chemo in 1st/ 2nd line with a best ORR of SD/PR/CR followed by a chemo-break, were re-treated with Cetux-chemo at PD. Cohort 2: A retrospective cohort of KRAS-WT patients (matched by age, sex, no. of sites of metastases (mets), prior Cetux-chemo and prior surgery) who received chemo without any targeted therapy at PD following a chemo-break. The primary objective was to compare the overall response rate (ORR) of cohort 1 & 2, secondary objectives included disease control rate (DCR) & progression free survival (PFS).


22 eligible pts were enrolled in cohort 1 across two centers in Hong Kong: median age 58yrs, M:F ratio= 1:1; site of metastases (mets) = solitary 36.3%, > 1 site 63.7%. None had prior bevacizumab; prior Cetux as 1st line = 77.3% & as 2nd line = 22.7%. In 21 evaluable pts, ORR = 52.4%, SD 33.3%, PD 14.3% & DCR 85.7%. The median OS for cohort 1 = 18.6 ms (95% CI: 11.1-27.1) & 1-yr PFS 36.4%. In cohort 2, 22 matching KRAS-WT patients were identified. The ORR for cohort 2 = 31.8%, DCR 50%, median OS 11ms (95% CI: 4.5-17.1) & 1-yr PFS 22.7%. In a regression analysis which included other prognostic variables (age, sex, prior no. of line of chemo, no. of sites of mets), DCR was the only significantly different factor (odd ratio, OR 6.0, 95% CI: 1.365-26.371, p = 0.018) favouring cohort 1. There was a non-significant trend favouring cohort 1 in ORR (52.4% vs 31.8 %, p = 0.171) and median PFS (8.1ms vs 5.3ms, p = 0.524).


The data suggests that in pts who had prior Cetux-chemo in the 1st or 2nd line treatment of mCRC, re-introduction of Cetux-chemo following a chemo-break was effective in most patients.

Editorial acknowledgement

Clinical trial identification


Legal entity responsible for the study

Brigette Ma.


Merck Serono.


B.B.Y. Ma: Speaker\'s honorarium: Merck Serono. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.