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Poster display - Cocktail

1386 - Weekly Docetaxel Concurrent Chemoradiotherapy Versus Cisplatin in Locorgionally Advanced Nasopharyngeal Carcinoma: A Propensity Matched Analysis


24 Nov 2018


Poster display - Cocktail


Jun Liao


Annals of Oncology (2018) 29 (suppl_9): ix94-ix104. 10.1093/annonc/mdy438


J.F. Liao

Author affiliations

  • Radiation Oncology, Sun Yat-sen University Cancer Center, 510000 - Guangzhou/CN


Abstract 1386


Previous study has reported taxane-based concurrent therapy had equivalent efficacy to platinum in head and neck squamous cell carcinom. However, studies about concurrent chemoradiation of docetaxel alone in NPC are limited.This study aimed to compare the effectiveness and toxicities of weekly docetaxel versus tri-weekly cisplatin concurrent chemoradiotherapy for locoregionally advanced NPC.


From January 2010 to December 2014, patients with newly diagnosed locoregionally advanced nasopharyngeal carcinoma receiving either weekly docetaxel or tri-weekly cisplatin were retrospectively reviewed. Propensity score matchingan alysis was used to balance baseline characteristics between treatment arms. Data from 962 patients were included in the analysis, and the propensity matched cohort included 448 patients in total.


The median follow-up duration is 47 months among the matched cohort.3-year nodal recurrence-free survival was significantly improved for patients treated with docetaxel compared to cisplatin (HR,0.33; 95%CI 0.12 to 0.90, P = 0.020), however,there were no differences in 3-year overall survival, local relapse-free survival, and distant-metastasis free survival between two groups. In subgroup analysis, cisplatin showed a trend towards improving distant metastasis free survival (89.2%vs.78.1%,P=0.075) which did not reach statistical significance in patients with pretreatment levels of Epstein-Barr VirusDNA≥4000 copy/mL. Significant higher incidence of grade 3/4 radiodermatitis (7.1%vs.1.6%,P=0.001) and mucositis (78.8%vs.45.5%,P<0.001)were observed in docetaxel group, but renal injury (1.8%vs. 15.1%, P < 0.01),vomiting(19.6% vs 93%, P < 0.01), hepatic injury (18.8%vs.31.3%,P<0.027), and grade 3/4 hematologicaltoxicity (2.2%vs.14.3%, P < 0.01) were more common in cisplatin group.


Weekly low-dose docetaxel concurrent chemoradiotherapyis an effective and toxicity tolerable method for locally advanced NPC.It provides a survival benefit mainly by improving regional control especially for patients with low EBV DNA levels. As forpatients with EBV DNA ≥4000 copy/mL, concurrent cisplatin seemsto be more efficacious.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Sun Yat-sen University Cancer Center.


Has not received any funding.


The author has declared no conflicts of interest.

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